European Journal of Chemistry 2014, 5(4), 595-600 | doi: https://doi.org/10.5155/eurjchem.5.4.595-600.1106 | Get rights and content






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Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety


Moustafa Ahmed Gouda (1,*) , Hadeer Fakhr Eldien (2) , Margret Mansour Girges (3) , Moged Ahmed Berghot (4)

(1) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(2) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(3) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(4) Chemistry Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt
(*) Corresponding Author

Received: 11 Jun 2014 | Revised: 12 Jul 2014 | Accepted: 12 Jul 2014 | Published: 31 Dec 2014 | Issue Date: December 2014

Abstract


A few new sulphadimidine incorporating thiophene moiety are synthesized. These compounds were assessed by analytical and spectral data. Antioxidant evaluation for the investigated compounds was evaluated by ABTS assay and bleomycin-dependent DNA-damage; the compounds exhibited weak activities.


Keywords


Thiophene; Pyrimidine; Sulphadimidine; Cyanoacetamide; Cyanoacetylation; Antioxidant evaluation

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DOI: 10.5155/eurjchem.5.4.595-600.1106

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How to cite


Gouda, M.; Eldien, H.; Girges, M.; Berghot, M. Eur. J. Chem. 2014, 5(4), 595-600. doi:10.5155/eurjchem.5.4.595-600.1106
Gouda, M.; Eldien, H.; Girges, M.; Berghot, M. Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety. Eur. J. Chem. 2014, 5(4), 595-600. doi:10.5155/eurjchem.5.4.595-600.1106
Gouda, M., Eldien, H., Girges, M., & Berghot, M. (2014). Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety. European Journal of Chemistry, 5(4), 595-600. doi:10.5155/eurjchem.5.4.595-600.1106
Gouda, Moustafa, Hadeer Fakhr Eldien, Margret Mansour Girges, & Moged Ahmed Berghot. "Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety." European Journal of Chemistry [Online], 5.4 (2014): 595-600. Web. 6 Jun. 2020
Gouda, Moustafa, Eldien, Hadeer, Girges, Margret, AND Berghot, Moged. "Synthesis and antioxidant evaluation of some new sulphadimidine incorporating thiophene moiety" European Journal of Chemistry [Online], Volume 5 Number 4 (31 December 2014)

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DOI Link: https://doi.org/10.5155/eurjchem.5.4.595-600.1106

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