European Journal of Chemistry 2014, 5(4), 676-680 | doi: https://doi.org/10.5155/eurjchem.5.4.676-680.1110 | Get rights and content




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PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines


Shankaraiah Guruvaiah Konda (1,*)

(1) Department of Chemistry, Karamsibhai Jethabhai Somaiya College of Arts, Commerce and Science, Kopargaon, 423601, India
(*) Corresponding Author

Received: 20 Jun 2014 | Accepted: 09 Aug 2014 | Published: 31 Dec 2014 | Issue Date: December 2014

Abstract


An efficient and convenient route is described for the synthesis of new pyrazolo [1,5-a] pyrimidine derivatives by the reaction of 4-(4’-chloro-phenylazo)-5-amino pyrazole with α,β-unsaturated carbonyl compounds (chalcones) using polyethylene glycol (PEG-400) as benign reaction medium. The advantage of this protocol includes the excellent yields, operational simplicity, short reaction times and avoidance of volatile organic solvents and expensive catalysts.


Keywords


PEG-400; Recyclability; Benign synthesis; 5-Amino pyrazole; α,β-Unsaturated ketones; Pyrazolo[1,5-a]pyrimidine

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DOI: 10.5155/eurjchem.5.4.676-680.1110

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Citations

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[1]. Douaa Salman AlMarzouq, Omniya Sayed Zaky, Abdulaziz Abdulrazaq AlNajjar, Kamal Usef Sadek
Pressure as effective green technology for synthesis of polyfunctionally substituted heteroaromatics: Synthesis of a variety of pyrazolo[1,5-a]pyrimidines
European Journal of Chemistry  7(3), 347, 2016
DOI: 10.5155/eurjchem.7.3.347-351.1473
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[2]. Mohammed Loubidi, Catherine Manga, Zahira Tber, Ibtissam Bassoude, El Mokhtar Essassi, Sabine Berteina-Raboin
One-Pot SN Ar/Direct Pd-Catalyzed CH Arylation Functionalization of Pyrazolo[1,5-a ]pyrimidine at the C3 and C7 Positions
European Journal of Organic Chemistry  2018(29), 3936, 2018
DOI: 10.1002/ejoc.201800580
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How to cite


Konda, S. Eur. J. Chem. 2014, 5(4), 676-680. doi:10.5155/eurjchem.5.4.676-680.1110
Konda, S. PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines. Eur. J. Chem. 2014, 5(4), 676-680. doi:10.5155/eurjchem.5.4.676-680.1110
Konda, S. (2014). PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines. European Journal of Chemistry, 5(4), 676-680. doi:10.5155/eurjchem.5.4.676-680.1110
Konda, Shankaraiah. "PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines." European Journal of Chemistry [Online], 5.4 (2014): 676-680. Web. 13 Dec. 2019
Konda, Shankaraiah. "PEG-400: An efficient and recyclable reaction medium for the synthesis of pyrazolo[1,5-a]pyrimidines" European Journal of Chemistry [Online], Volume 5 Number 4 (31 December 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.4.676-680.1110

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