European Journal of Chemistry

DABCO as an efficient catalyst for the synthesis of 3-cyano-2(1H)-pyridinones and their 2-imino analogues



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Yahia Shirazi Beheshtia
Maliheh Khorshidi
Majid Momahed Heravi
Bita Baghernejad

Abstract

3-cyano-2(1H)-pyridinones and their 2-imino analogues have been synthesized in good yields via a one-pot multi-component reaction of 3,4-dimethoxyacetophenone, malononitrile or ethylcyanoacetate, ammonium acetate and various aldehydes in the presence of  1,4-diaza-bicyclo[2,2,2]octane (DABCO) in ethanol. DABCO has been widely used as a catalyst for the organic reactions and we selected it as an efficient catalyst to synthesis of 3-cyano-pyridines. All products were characterized by melting point, IR, 1H NMR and GC/MS studies.

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Beheshtia, Y. S.; Khorshidi, M.; Heravi, M. M.; Baghernejad, B. DABCO As an Efficient Catalyst for the Synthesis of 3-Cyano-2(1H)-Pyridinones and Their 2-Imino Analogues. Eur. J. Chem. 2010, 1, 232-235.

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