European Journal of Chemistry 2015, 6(1), 31-36 | doi: https://doi.org/10.5155/eurjchem.6.1.31-36.1138 | Get rights and content






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Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples


Baharak Sehatnia (1) , Reza Emamali Sabzi (2,*) , Farshad Kheiri (3) , Abbas Nikoo (4)

(1) Department of Chemistry, Faculty of Science, Urmia University, Urmia, 165, Iran
(2) Department of Chemistry, Faculty of Science, Urmia University, Urmia, 165, Iran
(3) Department of Chemical Engineering, Faculty of Chemical Engineering, Urmia University of Technology, Urmia, 165, Iran
(4) Department of Chemistry, Faculty of Science, Urmia University, Urmia, 165, Iran
(*) Corresponding Author

Received: 26 Aug 2014 | Revised: 29 Sep 2014 | Accepted: 01 Oct 2014 | Published: 31 Mar 2015 | Issue Date: March 2015

Abstract


In the present work, a new Graphene-TiO2 (GR-TiO2) modified glassy carbon electrode (GCE) is suggested for sensitive electrochemical determination of metronidazole (MTZ). Electrochemical studies revealed that GR-TiO2 nanoparticles increased the efficiency of electron transfer kinetics by increasing the available surface area of the electrode and charge mobility between MTZ and GR-TiO2 modified electrode. Compared to bare GCE, the modified electrode greatly enhanced the reduction signal of MTZ. The electrochemical behaviour of the modified electrode and the electrochemical reduction of MTZ were investigated with electrochemical impedance spectroscopy, cyclic voltammetry and differential pulse voltammetry techniques. The charge transfer coefficient (α) was calculated to be 0.694. Under optimized conditions, the linear concentration range and detection limit of MTZ were 5.0×10-7 to 2.5×10-5 M-1 and 5.4×10-8 (S/N = 3), respectively. Finally, this sensing method was successfully applied for the determination of MTZ in human blood serum and urine samples.

 

 


Keywords


Graphene; Metronidazole; TiO2 nanoparticles; Cyclicvoltammetry; Differential pulse voltammetry; Electrochemical impedance spectroscopy

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DOI: 10.5155/eurjchem.6.1.31-36.1138

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Urmia University, Urmia, 165, Iran

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How to cite


Sehatnia, B.; Sabzi, R.; Kheiri, F.; Nikoo, A. Eur. J. Chem. 2015, 6(1), 31-36. doi:10.5155/eurjchem.6.1.31-36.1138
Sehatnia, B.; Sabzi, R.; Kheiri, F.; Nikoo, A. Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples. Eur. J. Chem. 2015, 6(1), 31-36. doi:10.5155/eurjchem.6.1.31-36.1138
Sehatnia, B., Sabzi, R., Kheiri, F., & Nikoo, A. (2015). Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples. European Journal of Chemistry, 6(1), 31-36. doi:10.5155/eurjchem.6.1.31-36.1138
Sehatnia, Baharak, Reza Emamali Sabzi, Farshad Kheiri, & Abbas Nikoo. "Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples." European Journal of Chemistry [Online], 6.1 (2015): 31-36. Web. 6 Jun. 2020
Sehatnia, Baharak, Sabzi, Reza, Kheiri, Farshad, AND Nikoo, Abbas. "Sensitive determination of metronidazole based on Graphene-TiO2 modified glassy carbon electrode in human serum and urine samples" European Journal of Chemistry [Online], Volume 6 Number 1 (31 March 2015)

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DOI Link: https://doi.org/10.5155/eurjchem.6.1.31-36.1138

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