European Journal of Chemistry 2010, 1(4), 262-265 | doi: https://doi.org/10.5155/eurjchem.1.4.262-265.116 | Get rights and content






  OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection


Karunanidhi Lakshmi (1) , Tirumala Rajesh (2,*)

(1) Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramasamy Memorial University, Kattankulathur, IN-603203, Tamil Nadu, India
(2) Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramasamy Memorial University, Kattankulathur, IN-603203, Tamil Nadu, India
(*) Corresponding Author

Received: 20 May 2010 | Revised: 23 Jun 2010 | Accepted: 24 Jun 2010 | Published: 22 Dec 2010 | Issue Date: December 2010

Abstract


Voglibose is a potent glucosidase inhibitor used for type II diabetes mellitus. A simple and rapid high performance liquid chromatographic method with refractive index detection was developed for the determination of voglibose in pharmaceutical formulations. Development was performed on a C18 (250 x 4.6 mm, 5 µ) column using a mobile phase mixture of acetonitrile and water in the ratio of 50:50 which was fixed at a flow rate of 0.5 mL/min. Polarity of voglibose was found to be positive and elution time was found to be less than 5 min. The method was also validated as per ICH guidelines for its linearity, precision, accuracy and robustness. The limit of detection and quantification (LOD and LOQ) were found to be 2.91 and 9.7 µg/mL. The method could be successfully applied for the quantification of voglibose in pharmaceutical formulations.

1_4_262_265_800


Keywords


Voglibose; HPLC; RID; Validation; Pharmaceutical formulations

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.1.4.262-265.116

Links for Article


| | | | | | |

| | | | | | |

Related Articles




Article Metrics

This Abstract was viewed 1609 times | PDF Article downloaded 752 times

Funding information


University Grants Commission, New Delhi, India

Citations

/


[1]. Masoom Raza Siddiqui, Zeid A. AlOthman, Nafisur Rahman
Analytical techniques in pharmaceutical analysis: A review
Arabian Journal of Chemistry  10, S1409, 2017
DOI: 10.1016/j.arabjc.2013.04.016
/


[2]. R. Solaichamy, J. Karpagam
Structural and Vibrational Studies (FT-IR, FT-Raman) of Voglibose Using DFT Calculation
International Letters of Chemistry, Physics and Astronomy  64, 45, 2016
DOI: 10.18052/www.scipress.com/ILCPA.64.45
/


[3]. Yongjin Sung
Snapshot Holographic Optical Tomography
Physical Review Applied  11(1), , 2019
DOI: 10.1103/PhysRevApplied.11.014039
/


References

[1]. Yamasaki, Y.; Katakami, N.; Hayaishi-Okano, R.; Matsuhisa, M.; Kajimoto, Y.; Kosugi, K.; Hatano, M.; Hori, M. Diabetes Res. Clin. Pract. 2005, 67, 204-210.
doi:10.1016/j.diabres.2004.07.012
PMid:15713352

[2]. Watanabe, K.; Uchino, H.; Ohmura, C.; Tanaka, Y.; Onuma, T.; Kawamori, R. J. Diabetes Complicat. 2004, 18, 183-186.
doi:10.1016/S1056-8727(03)00055-2

[3]. Vichayanrat, A.; Ploybutr, S.; Tunlakit, M.; Watanakejorn, P. Diabetes Res. Clin. Pract. 2002, 55, 99-103.
doi:10.1016/S0168-8227(01)00286-8

[4]. Zhang, H.; Sun, C. R.; Ishurd, O.; Pan, Y.J.; Ding, L.S. Carbohydr. Res. 2004, 339, 2027-2030.
doi:10.1016/j.carres.2004.05.025
PMid:15261596

[5]. Chen, X.; Zheng, Y.; Shen, Y. Curr. Med. Chem. 2006, 13, 109-116.
doi:10.2174/092986706789803035
PMid:16457643

[6]. Rethfeld, I.; Blaschke, G. J. Chromatogr. B 1997, 700, 249-253.
doi:10.1016/S0378-4347(97)00333-2

[7]. Woo. J. S.; Ryu, J. K. J. Pharm. Biomed. Anal. 2006, 42, 328-333.
doi:10.1016/j.jpba.2006.04.018
PMid:16730153

[8]. Saiz-Abajo, M. J.; Gonzalez-Saiz, J. M.; Consuelo, P. Anal. Chim. Acta 2005, 528, 63-76.
doi:10.1016/j.aca.2004.06.027

[9]. ICH Guidelines, Validation of Analytical Procedures: Q2A, 1994.

[10]. ICH Guidelines, Validation of Analytical Procedures: Q2B, 1996.

[11]. ICH Draft Guidelines, Validation of Analytical Procedures: Definitions and Terminology, Federal Register, vol. 60, IFPMA, Switzerland, 1995.

How to cite


Lakshmi, K.; Rajesh, T. Eur. J. Chem. 2010, 1(4), 262-265. doi:10.5155/eurjchem.1.4.262-265.116
Lakshmi, K.; Rajesh, T. Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection. Eur. J. Chem. 2010, 1(4), 262-265. doi:10.5155/eurjchem.1.4.262-265.116
Lakshmi, K., & Rajesh, T. (2010). Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection. European Journal of Chemistry, 1(4), 262-265. doi:10.5155/eurjchem.1.4.262-265.116
Lakshmi, Karunanidhi, & Tirumala Rajesh. "Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection." European Journal of Chemistry [Online], 1.4 (2010): 262-265. Web. 13 Jul. 2020
Lakshmi, Karunanidhi, AND Rajesh, Tirumala. "Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection" European Journal of Chemistry [Online], Volume 1 Number 4 (22 December 2010)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item


DOI Link: https://doi.org/10.5155/eurjchem.1.4.262-265.116

| | | | | | |

| | | | | |

Save to Zotero Save to Mendeley



European Journal of Chemistry 2010, 1(4), 262-265 | doi: https://doi.org/10.5155/eurjchem.1.4.262-265.116 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)




© Copyright 2010 - 2020  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2020 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.

hatay escort hatay escort corlu escort corum escort burgaz escort giresun escort aydin escort ordu escort erzincan escort hatay escort sivas escort rize escort edirne escort aksaray escort kibris escort isparta escort erzurum escort tekirdag escort usak escort urfa escort kastamonu escort kibris escort manisa escort giresun escort urfa escort nevsehir escort sivas escort yalova escort ordu escort hatay escort yalova escort amasya escort kayseri escort ordu escort maras escort canakkale escort yalova escort balikesir escort manisa escort urfa escort mugla escort trabzon escort bolu escort corlu escort diyarbakir escort isparta escort kutahya escort elazig escort erzurum escort sakarya escort afyon escort kutahya escort konya escort agri escort cesme escort sinop escort sivas escort konya escort kibris escort adapazari escort luleburgaz escort adana escort kibris escort rize escort sakarya escort alanya escort isparta escort burdur escort konya escort bitlis escort canakkale escort sivas escort amasya escort mus escort aydin escort van escort yalova escort kastamonu escort mardin escort bolu escort afyon escort sakarya escort isparta escort tokat escort trakya escort bayburt escort urfa escort mardin escort