European Journal of Chemistry 2015, 6(3), 270-274 | doi: https://doi.org/10.5155/eurjchem.6.3.270-274.1242 | Get rights and content






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Synthesis of some novel benzimidazole derivatives and their biological evaluation


Dnyandev Radhu Gund (1) , Balivada Venkata Satyasai Varaprasad Rao (2) , Pandurang Narayanrao Mandhare (3) , Sanjay Dashrath Vaidya (4,*)

(1) Department of Chemistry, Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, 333001, India
(2) Department of Chemistry, Pacific University, Udaipur, Rajasthan, 313024, India
(3) Department of Chemistry, Shreemati Nathibai Damodar Thackersey Women’s University, Mumbai, 400049, India
(4) Department of Chemistry, Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Rajasthan, 333001, India
(*) Corresponding Author

Received: 11 Jan 2015 | Revised: 05 Apr 2015 | Accepted: 05 Apr 2015 | Published: 30 Sep 2015 | Issue Date: September 2015

Abstract


A series of novel benzimidazole derivatives have been synthesized by the condensation of o-phenylenediamine with 4-bromophenoxy acetic acid and product obtained was alkylated at the benzimidazole -NH with different electrophilic reagents. Subsequent reactions of the products by the Suzuki Coupling between benzimidazole derivatives and phenylboronic acid derivatives were accomplished. All these compounds were characterized by FT-IR, 1H NMR, MS and elemental analysis. These compounds were screened for their potential antibacterial and antifungal activities. This exhibited some promising results towards testing organism in-vitro.


Keywords


Alkylation; Benzimidazole; Suzuki coupling; Antifungal activity; Phenyl boronic acid; Antibacterial activity

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DOI: 10.5155/eurjchem.6.3.270-274.1242

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Funding information


Analytical Instrumentation Facility, Punjab University, India

Citations

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[1]. Dnyandev Radhu Gund, Alok Pramod Tripathi, Sanjay Dashrath Vaidya
Synthesis and antimicrobial activity of some novel N-substituted benzimidazoles
European Journal of Chemistry  8(2), 149, 2017
DOI: 10.5155/eurjchem.8.2.149-154.1563
/


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How to cite


Gund, D.; Rao, B.; Mandhare, P.; Vaidya, S. Eur. J. Chem. 2015, 6(3), 270-274. doi:10.5155/eurjchem.6.3.270-274.1242
Gund, D.; Rao, B.; Mandhare, P.; Vaidya, S. Synthesis of some novel benzimidazole derivatives and their biological evaluation. Eur. J. Chem. 2015, 6(3), 270-274. doi:10.5155/eurjchem.6.3.270-274.1242
Gund, D., Rao, B., Mandhare, P., & Vaidya, S. (2015). Synthesis of some novel benzimidazole derivatives and their biological evaluation. European Journal of Chemistry, 6(3), 270-274. doi:10.5155/eurjchem.6.3.270-274.1242
Gund, Dnyandev, Balivada Venkata Satyasai Varaprasad Rao, Pandurang Narayanrao Mandhare, & Sanjay Dashrath Vaidya. "Synthesis of some novel benzimidazole derivatives and their biological evaluation." European Journal of Chemistry [Online], 6.3 (2015): 270-274. Web. 30 Nov. 2020
Gund, Dnyandev, Rao, Balivada, Mandhare, Pandurang, AND Vaidya, Sanjay. "Synthesis of some novel benzimidazole derivatives and their biological evaluation" European Journal of Chemistry [Online], Volume 6 Number 3 (30 September 2015)

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DOI Link: https://doi.org/10.5155/eurjchem.6.3.270-274.1242

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