European Journal of Chemistry 2015, 6(3), 319-324 | doi: https://doi.org/10.5155/eurjchem.6.3.319-324.1278 | Get rights and content






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Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods


Maha Abdel Monem Hegazy (1) , Medhat Ahmed Al-Ghobashy (2) , Basma Mohamed Eltanany (3,*) , Fatma Issa Khattab (4)

(1) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11511, Egypt
(2) Bioanalysis Research Group, Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11511, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11511, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, 11511, Egypt
(*) Corresponding Author

Received: 04 Jun 2015 | Accepted: 05 Jul 2015 | Published: 30 Sep 2015 | Issue Date: September 2015

Abstract


Sodium cromoglycate (SCG) and oxymetazoline hydrochloride (OXMT) are administered in combination for effective treatment of nasal congestion and allergy. In this work, SCG was determined using direct spectrophotometry by measuring its zero order absorption spectra at its λmax 320.6 nm where OXMT showed zero absorbance. On the other hand, four simple, sensitive and precise spectrophotometric methods were developed and validated for the determination of OXMT in the presence of SCG in their laboratory prepared mixtures and pharmaceutical formulation, without preliminary separation; Method A: first derivative spectrophotometric method [1D], Method B: first derivative of ratio spectra method [1DD], Method C: ratio difference spectrophotometric method [RDSM] and Method D: ratio subtraction method [RSM]. Ratio manipulating methods (Method B, C and D) were done using divisor of 10.00 µg/mL SCG. Linear correlation was obtained in range 4-22 µg/mL for OXMT by methods A, B and D and 6-22 µg/mL for method C. All methods were validated in compliance with the International Conference on Harmonization (ICH) guidelines and satisfactory results were obtained. No significant difference was noted between the developed methods and the official one with respect to accuracy and precision.


Keywords


First derivative; Ratio difference; Ratio subtraction; Sodium cromoglycate; Simultaneous determination; Oxymetazoline hydrochloride

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DOI: 10.5155/eurjchem.6.3.319-324.1278

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[1]. Maha A. Hegazy, May H. Abdelwahab, Hassan A. M. Hendawy, Soheir A. Weshahy, Samah S. Abbas
Validated HPTLC and HPLC methods for determination of fluorometholone and sodium cromoglycate in presence of their impurities and degradation products; application to kinetic study and on rabbit aqueous humor
Journal of Liquid Chromatography & Related Technologies  41(5), 203, 2018
DOI: 10.1080/10826076.2018.1431926
/


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How to cite


Hegazy, M.; Al-Ghobashy, M.; Eltanany, B.; Khattab, F. Eur. J. Chem. 2015, 6(3), 319-324. doi:10.5155/eurjchem.6.3.319-324.1278
Hegazy, M.; Al-Ghobashy, M.; Eltanany, B.; Khattab, F. Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods. Eur. J. Chem. 2015, 6(3), 319-324. doi:10.5155/eurjchem.6.3.319-324.1278
Hegazy, M., Al-Ghobashy, M., Eltanany, B., & Khattab, F. (2015). Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods. European Journal of Chemistry, 6(3), 319-324. doi:10.5155/eurjchem.6.3.319-324.1278
Hegazy, Maha, Medhat Ahmed Al-Ghobashy, Basma Mohamed Eltanany, & Fatma Issa Khattab. "Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods." European Journal of Chemistry [Online], 6.3 (2015): 319-324. Web. 19 Jan. 2020
Hegazy, Maha, Al-Ghobashy, Medhat, Eltanany, Basma, AND Khattab, Fatma. "Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods" European Journal of Chemistry [Online], Volume 6 Number 3 (30 September 2015)

DOI Link: https://doi.org/10.5155/eurjchem.6.3.319-324.1278

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