European Journal of Chemistry 2015, 6(4), 417-421. doi:10.5155/eurjchem.6.4.417-421.1310

Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin


Muhammad Islam (1) , Zahid Shafiq (2,*) , Mazhar Hussain (3) , Hafiz Badaruddin Ahmad (4) , Muhammad Ajaz Hussain (5)

(1) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(2) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(3) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(4) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(5) Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan
(*) Corresponding Author

Received: 13 Aug 2015, Accepted: 19 Sep 2015, Published: 31 Dec 2015

Abstract


Some novel imine derivatives (1-14) of a broad spectrum antibiotic amoxicillin were prepared by condensation with different carbonyl compounds. The amoxicillin imine derivatives were characterized using elemental analysis and spectroscopic techniques such as FT-IR and 1H NMR. The prepared imine derivatives were evaluated for antimicrobial activities against some pathogens using disc diffusion method. The results of present studies demonstrate enhanced antimicrobial activity of the novel imine derivatives of amoxicillin as compared to the parent drug.


Keywords


Antibiotics; Amoxicillin; Schiff’s base; Condensation; Imine derivatives; Antimicrobial activity

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DOI: 10.5155/eurjchem.6.4.417-421.1310

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How to cite


Islam, M.; Shafiq, Z.; Hussain, M.; Ahmad, H.; Hussain, M. Eur. J. Chem. 2015, 6(4), 417-421. doi:10.5155/eurjchem.6.4.417-421.1310
Islam, M.; Shafiq, Z.; Hussain, M.; Ahmad, H.; Hussain, M. Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin. Eur. J. Chem. 2015, 6(4), 417-421. doi:10.5155/eurjchem.6.4.417-421.1310
Islam, M., Shafiq, Z., Hussain, M., Ahmad, H., & Hussain, M. (2015). Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin. European Journal of Chemistry, 6(4), 417-421. doi:10.5155/eurjchem.6.4.417-421.1310
Islam, Muhammad, Zahid Shafiq, Mazhar Hussain, Hafiz Badaruddin Ahmad, & Muhammad Ajaz Hussain. "Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin." European Journal of Chemistry [Online], 6.4 (2015): 417-421. Web. 14 Nov. 2019
Islam, Muhammad, Shafiq, Zahid, Hussain, Mazhar, Ahmad, Hafiz, AND Hussain, Muhammad. "Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin" European Journal of Chemistry [Online], Volume 6 Number 4 (31 December 2015)

DOI Link: https://doi.org/10.5155/eurjchem.6.4.417-421.1310

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