OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS
Determination of dimenhydrinate and cinnarizine in combined dosage form in presence of cinnarizine impurity
Nada Sayed Abdelwahab (1) , Maha Mohammed Abdelrahman (2) , Fathy Mahmoud Salama (3) , Amal Badawy Ahmed (4,*)
(1) Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni‐Suef, 62514 Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni‐Suef, 62514 Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, El-Azhar University, Cairo, 11651, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Nahda University, Beni‐Suef, 62514 Egypt
(*) Corresponding Author
Received: 15 Sep 2015 | Accepted: 18 Oct 2015 | Published: 31 Dec 2015 | Issue Date: December 2015
Three accurate, sensitive and time saving spectrophotometric methods have been developed and validated for determination of mixture of dimenhydrinate (DMH) and cinnarizine (CIN) in presence of cinnarizine impurity (1-(diphenylmethyl)piperazine) (IMP). In method A; dimenhydrinate was determined by measuring 1D amplitudes at 292.0 nm while cinnarizine and its impurity were determined by 1DD method at 256.2 and 219.6 nm, respectively, using standard spectrum of 20 µg/mL of dimenhydrinate as a divisor. Method B depends on dividing spectrum of ternary mixture by standard spectrum of 20 µg/mL of dimenhydrinate and then cinnarizine and its impurity were determined in the obtained ratio spectrum by ratio difference method using the difference between 219.0 and 237.2 nm and between 230.0 and 264.0 nm, respectively. On the other hand dimenhydrinate could be determined by dividing spectrum of ternary mixture by standard spectrum of 20 µg/mL of cinnarizine and then it were determined at the obtained ratio spectrum by ratio difference method using the difference between 216.8 and 232.8 nm. Method C is the mean cantering of ratio spectra method (MCR) where the amplitudes at 234.8, 240.0 and 233.6 nm in the second mean centering ratio spectra were used for determination of dimenhydrinate, cinnarizine and its impurity, respectively. The developed methods were validated according to ICH guidelines regarding good accuracy and precision, and they were successfully applied to pharmaceutical formulation and laboratory prepared mixtures. The results were statistically compared with those obtained by reported method and no significant difference was found.
Links for Article
| | | | | | |
| | | | | | |
Article MetricsThis Abstract was viewed 1009 times | PDF Article downloaded 292 times
. Nehal Fayek Farid, Nada Sayed Abdelwahab
Eco-friendly UPLC method for determination of Levetiracetam and its toxic related substance
European Journal of Chemistry 7(3), 329, 2016
. Shereen M. Tawakkol, Mohamed B. El-Zeiny, A. Hemdan
Full spectrum and selected spectrum based chemometric methods for the simultaneous determination of Cinnarizine and Dimenhydrinate in laboratory prepared mixtures and pharmaceutical dosage form
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 173, 892, 2017
. Budavaried, S. The Merck Index: An encyclopedia of chemicals, drugs and biological, 40th Ed., Merck & Co., Inc., Whitehouse Station, NJ, USA, 2006.
. Profitt, K. Martindale, The extra Pharmacopeia: The complete drug reference, 35th Ed., Royal Pharmaceutical Society, London, UK, 2006.
. British Pharmacopoeia, Vol. II, Stationary Office, Medicines and Health care Products Regulatory Agency, London, UK, 2010.
. European Pharmacopoeia, 6th Edi., European Department for the Quality of Medicines within the Council of Europe, Strasbourg, France, 2008
. The United States Pharmacopoeia, 32th revision, NF 27, The United States Pharmacopoeial Convention Inc., Rockville, MD, 2009.
. Shah, P.B.; Patel, P. U. J. Pharm. Sci. Bio-Sci. Res. 2012, 2(2), 83-87.
. Dalwadi, N.; Chhalotiya, U. K.; Shah, D.; Mehta, F.; Bhatt, K. Int. J. Adv. Pharm. Anal. 2014, 4(2), 58-61.
. Patel, A. P.; Kadikar, H. K.; Shah, R. R.; Shukla, M. H.; Tank, P. K. Pharma Sci. Mon. Int. J. Pharm. Sci. 2012, 3(4), 2493-2505.
. Lamie, N. T. Spectrochim. Acta A 2015, 141, 193-201.
. El-Kafrawy, D. S.; Belal, T. S. J. Assoc. Arab Univ. Basic Appl. Sci. 2014, doi:10.1016/j.jaubas.2014.06.004.
. Khushbu, S.; Pinkal, P. Int. J. Pharm. Sci. Res. 2014, 5(11), 4815-4819.
. Lamie, N. T.; Monir, H. H. J. Chromatogr. Sci. 2015, doi:10.1093/chromsci/bmv103
. International conference on the harmonization of technical requirements for the registration of pharmaceuticals for human use (ICH) Q2 (R1) Validation of Analytical Procedures: Text and Methodology. ICH Harmonized Tripartite Guideline, 2005.
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.6.4.475-481.1324
| | | | | | |
| | | | | |
Save to Zotero Save to Mendeley
European Journal of Chemistry 2015, 6(4), 475-481 | doi: https://doi.org/10.5155/eurjchem.6.4.475-481.1324 | Get rights and content
- There are currently no refbacks.
© Copyright 2010 - 2020 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2020 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.