European Journal of Chemistry 2016, 7(1), 102-106. doi:10.5155/eurjchem.7.1.102-106.1374

Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro


Wasfi Aboud Al-Masoudi (1) , Rana Adnan Faaz (2) , Rafid Hmedan Al-Asadi (3,*) , Hazim Saad Jabbar (4)

(1) Department of Physiology and Chemistry, College of Veterinary, University of Basrah, Basrah 61001, Iraq
(2) Department of Microbiology, College of Veterinary, University of Basrah, Basrah 61001, Iraq
(3) Department of Chemistry, College of Education for Pure Sciences, University of Basrah, Basrah 61001, Iraq
(4) Department of Basic Sciences, College of Dentistry, University of Basrah, Basrah 61001, Iraq
(*) Corresponding Author

Received: 26 Nov 2015, Accepted: 02 Jan 2016, Published: 31 Mar 2016

Abstract


Palladium(II) and cobalt(II) complexes of Schiff base derived from 4-aminobenzene sulfonamide (Sulfonamide drug) were prepared by convenient method. Reaction of sulfonamide with 2-hydroxy-1-naphthaldehyde gave the Schiff base compound 1 in good yield. Treatment of compound 1 with CoCl2.6H2O and PdCl2yielded new metal complexes 2 and 3, respectively. The synthesized compounds were screened for their antibacterial activity against Escherichia coli, Bacillus cereus, Salmonella spp. and Staphylococcus aureus. Additionally, the compounds were tested for antifungal activity against Aspergillus niger and Candida albicans. Some compounds exhibited good antibacterial and antifungal activity. Molecular modeling studies were performed and showed hydrogen binding and hydrophobic interactions.


Keywords


Synthesis; Schiff base; Sulfonamide; Metal complexes; Modeling studies; Antimicrobial activity

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DOI: 10.5155/eurjchem.7.1.102-106.1374

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Citations

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[1]. Ibtihal Hassan Hatim, Wasfi Aboud Al-Masoudi, Rashad Fadhil Ghadhban
Synthesis, characterization and acute toxicity of new Schiff base derived from phenylethyl amine and 2-hydroxy naphthaldehyde
European Journal of Chemistry  10(1), 26, 2019
DOI: 10.5155/eurjchem.10.1.26-29.1790
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[2]. Winston Nxumalo, Andrew Dinsmore, Richard M. Mampa, Bernard Omondi
Reactions and effect of N-sulfonylpyrrole yielding metal complexes: Crystal structural studies
Polyhedron  129, 240, 2017
DOI: 10.1016/j.poly.2017.03.051
/


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How to cite


Al-Masoudi, W.; Faaz, R.; Al-Asadi, R.; Jabbar, H. Eur. J. Chem. 2016, 7(1), 102-106. doi:10.5155/eurjchem.7.1.102-106.1374
Al-Masoudi, W.; Faaz, R.; Al-Asadi, R.; Jabbar, H. Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro. Eur. J. Chem. 2016, 7(1), 102-106. doi:10.5155/eurjchem.7.1.102-106.1374
Al-Masoudi, W., Faaz, R., Al-Asadi, R., & Jabbar, H. (2016). Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro. European Journal of Chemistry, 7(1), 102-106. doi:10.5155/eurjchem.7.1.102-106.1374
Al-Masoudi, Wasfi, Rana Adnan Faaz, Rafid Hmedan Al-Asadi, & Hazim Saad Jabbar. "Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro." European Journal of Chemistry [Online], 7.1 (2016): 102-106. Web. 15 Nov. 2019
Al-Masoudi, Wasfi, Faaz, Rana, Al-Asadi, Rafid, AND Jabbar, Hazim. "Synthesis, antimicrobial activity and modelling studies of some new metal complexes of Schiff base derived from sulphonamide drug in vitro" European Journal of Chemistry [Online], Volume 7 Number 1 (31 March 2016)

DOI Link: https://doi.org/10.5155/eurjchem.7.1.102-106.1374

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