European Journal of Chemistry 2016, 7(3), 280-282 | doi: https://doi.org/10.5155/eurjchem.7.3.280-282.1431 | Get rights and content






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Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin


Wasfi Aboud Al-Masoudi (1,*) , Mohammed Ali Al-Diwan (2) , Orass Saad Khayoon (3)

(1) Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
(2) Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
(3) Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Basrah, Basrah, 61001, Iraq
(*) Corresponding Author

Received: 25 Mar 2016 | Revised: 26 Apr 2016 | Accepted: 29 Apr 2016 | Published: 30 Sep 2016 | Issue Date: September 2016

Abstract


Condensation of L-arginine with 4-hydroxy-3-methoxy benzaldehyde (vanillin) yielded a novel Schiff base derivative of arginine in good yield. This new Schiff base was characterized by elemental analysis, IR and 1H NMR spectroscopy. The toxicity of the compound was also assayed via the determination of their LD50 value by using Dixon method. Studied compound was found to have an LD50 of 718.6 mg/kg of body weight.


Keywords


Vanillin; Schiff base; L-Arginine; Amino acid; Acute toxicity; Median lethal dose

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DOI: 10.5155/eurjchem.7.3.280-282.1431

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Funding information


Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, Al-Basrah University, Iraq

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How to cite


Al-Masoudi, W.; Al-Diwan, M.; Khayoon, O. Eur. J. Chem. 2016, 7(3), 280-282. doi:10.5155/eurjchem.7.3.280-282.1431
Al-Masoudi, W.; Al-Diwan, M.; Khayoon, O. Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin. Eur. J. Chem. 2016, 7(3), 280-282. doi:10.5155/eurjchem.7.3.280-282.1431
Al-Masoudi, W., Al-Diwan, M., & Khayoon, O. (2016). Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin. European Journal of Chemistry, 7(3), 280-282. doi:10.5155/eurjchem.7.3.280-282.1431
Al-Masoudi, Wasfi, Mohammed Ali Al-Diwan, & Orass Saad Khayoon. "Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin." European Journal of Chemistry [Online], 7.3 (2016): 280-282. Web. 6 Jun. 2020
Al-Masoudi, Wasfi, Al-Diwan, Mohammed, AND Khayoon, Orass. "Synthesis, characterization and acute toxicity of new Schiff base derived from L-arginine and vanillin" European Journal of Chemistry [Online], Volume 7 Number 3 (30 September 2016)

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DOI Link: https://doi.org/10.5155/eurjchem.7.3.280-282.1431

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