European Journal of Chemistry 2016, 7(3), 329-333 | doi: https://doi.org/10.5155/eurjchem.7.3.329-333.1463 | Get rights and content






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Eco-friendly UPLC method for determination of Levetiracetam and its toxic related substance


Nehal Fayek Farid (1,*) , Nada Sayed Abdelwahab (2)

(1) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt
(2) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt
(*) Corresponding Author

Received: 07 Jun 2016 | Revised: 16 Jul 2016 | Accepted: 17 Jul 2016 | Published: 30 Sep 2016 | Issue Date: September 2016

Abstract


Nowadays, analytical chemistry society is aware of the hazardous influence of chemicals on both health and environment. Additionally, chemists are more interested in eco-friendly methods of analysis. Levetiracetam (LEV) is an antiepileptic drug with no significant interaction with other medications and so it is a safe treatment in elderly people. The toxic pyridine-2-ol is reported in British Pharmacopoeia to be LEV impurity C (IMP-C) and related substance. A highly sensitive eco-friendly UPLC method was introduced for the first time for analysis of LEV and its toxic IMP. Separation has been carried out on CN column using 0.1% aqueous sodium lauryl sulphate:acetonitrile (7:93, v:v) with UV scanning at 205 nm. USP recommendations for method validation have been followed with respect to linearity, accuracy, robustness and ruggedness. The developed method was successfully applied for quantitation of LEV in its tablets dosage form and statistical analysis with the reported method showed no significant difference at confidence limit of 95%. The short run time (<3 minutes) and high sensitivity are of the most advantageous of developed method over the reported one.


Keywords


UPLC; Impurity; Validation; Eco-friendly; Pyridine-2-ol; Levetiracetam

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DOI: 10.5155/eurjchem.7.3.329-333.1463

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Funding information


Sigma Pharmaceutical Industries, Quesna, Menoufia, Egypt.

Citations

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[1]. Hazim M. Ali, Mohammed Gamal, Nada S. Abdelwahab, Nehal F. Farid
Simple GC–MS method for analysis of Levetiracetam and process-related toxic impurity
Microchemical Journal  146, 1236, 2019
DOI: 10.1016/j.microc.2019.02.063
/


[2]. Nada S. Abdelwahab, Nehal F. Farid, Mohamed Elagawany, Esraa H. Abdelmomen
Efficient UPLC and CE methods for the simultaneous determination of azelastine hydrochloride and its genotoxic impurity
Biomedical Chromatography  32(11), e4346, 2018
DOI: 10.1002/bmc.4346
/


References

[1]. The British Pharmacopoeia, Her Majesty's Stationery Office (HMSO), London, 2007.

[2]. Martindale-Extra Pharmacopoeia, 34th Ed., The Complete Drug References, The pharmaceutical Press, London, UK, 2005.

[3]. Shihabi, Z. K.; Oles, K.; Hinsdale, M. J. Chromatogr. A 2003, 1004, 9-12.
http://dx.doi.org/10.1016/S0021-9673(03)00716-7

[4]. Tunca, R.; Sozmen, M.; Citil, M.; Karapehlivan, M.; Erginsoy, S.; Yapar, K. Exp. Toxicol. Pathol. 2009, 61, 243-255.
http://dx.doi.org/10.1016/j.etp.2008.05.011

[5]. Sai-Thanuja, V.; Chandan, R. S.; Gurupadayya, B. M.; Prathyusha, W.; Indupriya M. Indo Am. J. Pharm. Res. 2014, 4, 561-565.

[6]. Santosh, V. G.; Ashwini, A. K.; Madhuri, M. K. Int. J. Pharm. Pharm. Sci. 2014, 6, 121-125.

[7]. Contin, M.; Mohamed, S.; Albani F.; Riva R.; Baruzzi A. J. Chromatogr. B 2008, 873, 129-132.
http://dx.doi.org/10.1016/j.jchromb.2008.08.007

[8]. Martens-Lobenhoffer, J.; Bode-Boger, S. M. J. Chromatogr. B 2005, 819, 197-200.
http://dx.doi.org/10.1016/j.jchromb.2005.01.040

[9]. Pucci, V.; Bugamelli, F.; Mandrioli R.; Ferranti, A.; Kenndler E.; Raggi; M. A. J. Biomed. Chromatogr. 2004, 18, 37-44.
http://dx.doi.org/10.1002/bmc.289

[10]. Jignesh, S. S.; Vidyasagar G.; Barot, H. Der Pharm. Sinica 2012, 3, 576-589.

[11]. Can, NO.; Arli, G. J. AOAC Int. 2010, 93, 1077-1085.

[12]. Ghada, M. H.; Randa, A. A.; Eman A. A. J. Liq. Chromatogr. Relat. Technol. 2013, 36, 2568-2579.

[13]. Matar, K. M. J. Pharm. Biomed. Anal. 2008, 48, 822-828.
http://dx.doi.org/10.1016/j.jpba.2008.05.035

[14]. Guo, T.; Oswald, L. M.; Mendu, D. R.; Soldin, S. J. Clinica Chimica Acta 2007, 375, 115-118.
http://dx.doi.org/10.1016/j.cca.2006.06.022

[15]. Blonk, M. I.; Van der Nagel, B. C.; Smit, L. S.; Mathot A. A. J. Chromatogr. B 2010, 878, 675-681.
http://dx.doi.org/10.1016/j.jchromb.2010.01.037

[16]. Olah, E.; Bacsoi, G.; Fekete, J.; Sharma, V. K. J. Chromatogr. Sci. 2012, 50(3), 253-258
http://dx.doi.org/10.1093/chromsci/bmr053

[17]. Dong, Y. M.; An, Q.; Lu, N. W.; Li, N. Acta Chromatog. 2015, 27, 355-372.
http://dx.doi.org/10.1556/AChrom.27.2015.2.11

[18]. Green Solvents, http://molsync.com/demo/greensolvents.php

[19]. The United States Pharmacopeia, National Formulary 35, United States Pharmacopeia Convention Inc., 30th Ed., 2012.

[20]. Farid, N. F.; Abdelwahab, N. S. Spectrochim. Acta A 2015, 145, 360-367.
http://dx.doi.org/10.1016/j.saa.2015.03.009

[21]. Abdelwahab, N. S.; Farid, N. F. RSC Adv. 2014, 4, 30523-30529.
http://dx.doi.org/10.1039/C4RA03637A

[22]. Habib, N. M.; Abdelwhab, N. S.; Abdelrahman, M. M.; Ali, N. W. Anal. Chem. Lett. 2015, 5(6), 399-409.
http://dx.doi.org/10.1080/22297928.2016.1142895

[23]. Abdelwahab, N. S.; Abdelrahman, Salama, F. M.; Ahmed, A. B. Eur. J. Chem. 2015, 6(4), 475‐481.
http://dx.doi.org/10.5155/eurjchem.6.4.475-481.1324

[24]. Morcoss, M. M.; Abdelwahab, N. S.; Ali, N. W.; Elsaady, M. T. J. Iran Chem. Soc. 2016, DOI: 10. 1007/s13738-016-0881-3

[25]. Farid, N. F.; Naguib, I. A.; Mohamed, R. S.; El‐Ghobashy, M. R. Eur. J. Chem. 2016, 7(2), 201‐205.
http://dx.doi.org/10.5155/eurjchem.7.2.201-205.1421

[26]. Nemutlu, E.; Kir, S.; Ozyuncu, O.; Beksac, M. S. Chromatographia 2007, 66, S15-S24.
http://dx.doi.org/10.1365/s10337-007-0292-9

How to cite


Farid, N.; Abdelwahab, N. Eur. J. Chem. 2016, 7(3), 329-333. doi:10.5155/eurjchem.7.3.329-333.1463
Farid, N.; Abdelwahab, N. Eco-friendly UPLC method for determination of Levetiracetam and its toxic related substance. Eur. J. Chem. 2016, 7(3), 329-333. doi:10.5155/eurjchem.7.3.329-333.1463
Farid, N., & Abdelwahab, N. (2016). Eco-friendly UPLC method for determination of Levetiracetam and its toxic related substance. European Journal of Chemistry, 7(3), 329-333. doi:10.5155/eurjchem.7.3.329-333.1463
Farid, Nehal, & Nada Sayed Abdelwahab. "Eco-friendly UPLC method for determination of Levetiracetam and its toxic related substance." European Journal of Chemistry [Online], 7.3 (2016): 329-333. Web. 6 Jun. 2020
Farid, Nehal, AND Abdelwahab, Nada. "Eco-friendly UPLC method for determination of Levetiracetam and its toxic related substance" European Journal of Chemistry [Online], Volume 7 Number 3 (30 September 2016)

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DOI Link: https://doi.org/10.5155/eurjchem.7.3.329-333.1463

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