European Journal of Chemistry

Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine



Main Article Content

Maria Aqeel Khan
Farhana Batool
Asma Khatoon
Rabia Sadiq
Sher Rahman
Fatima Zehra Basha

Abstract

Dibenzoazepine represents an important class of heterocycles, exhibiting potent antidepressant and anticonvulsant activities. Beside, various modifications on this nucleus, amide analogs at N-5 position showed potent antidepressant activities. A previously reported method for the synthesis of benzamide analogs of dibenzoazepine use hazardous and toxic solvents. Herein, we report a new, efficient and solvent-free green method for the synthesis of dibenzoazepine benzamides (6-21).


icon graph This Abstract was viewed 1391 times | icon graph Article PDF downloaded 598 times

How to Cite
(1)
Khan, M. A.; Batool, F.; Khatoon, A.; Sadiq, R.; Rahman, S.; Basha, F. Z. Solvent-Free Protocol for the Green Synthesis of Benzamide Analogs of Dibenzoazepine. Eur. J. Chem. 2017, 8, 179-182.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. Kumar, H. V.; Kumar, P.; Rangaswamy, J.; Sindhu, K. U.; Naik, N. Eur. J. Chem. 2015, 6, 394-403.
https://doi.org/10.5155/eurjchem.6.4.394-403.1297

[2]. Manjunath, B. C.; Kumar, K. S. V.; Kumar, S. M.; Sadashiva M. P.; Lokanath, N. K. Acta Cryst. E 2013, 69, o1763-o1763.
https://doi.org/10.1107/S1600536813030547

[3]. Yousuf, S.; Khan, M.; Fazal, S.; Butt, M.; Basha, F. Z. Acta Cryst. E 2012, 68, o1101-o1101.
https://doi.org/10.1107/S1600536812007866

[4]. Patton, J. R.; Dudley, K. H. J. Heterocyclic Chem. 1979, 16, 257-262.
https://doi.org/10.1002/jhet.5570160213

[5]. Chang, V. H. T. J. Heterocyclic Chem. 1983, 20, 237-238.
https://doi.org/10.1002/jhet.5570200149

[6]. Kovacs, N.; Nagy, F.; Balas, I.; Komoly, S.; Janszky, J. Epilepsy Behav. 2008, 12, 492-493.
https://doi.org/10.1016/j.yebeh.2007.12.010

[7]. Khan, M. A.; Saleem, A.; Ghouri, N.; Hameed, A.; Choudhary, M. I.; Basha, F. Z. Lett. Drug. Des. Discov. 2015, 12, 597-606.
https://doi.org/10.2174/1570180812999150225111959

[8]. Kumar, H. V.; Naik, N. Eur. J. Med. Chem. 2010, 45, 2-10.
https://doi.org/10.1016/j.ejmech.2009.09.016

[9]. Takayama, H.; Yaegashi, Y.; Kitajima, M.; Han, X.; Nishimura, K.; Okuyama, S.; Igarashi, K. Bioorg. Med. Chem. Lett. 2007, 17, 4729-4732.
https://doi.org/10.1016/j.bmcl.2007.06.069

[10]. Bag, S.; Tawari, N. R.; Degani, M. S.; Queener, S. F. Bioorg. Med. Chem. 2010, 18, 3187-3197.
https://doi.org/10.1016/j.bmc.2010.03.031

[11]. Confalone, P. N.; Huie, E. M. J. Org. Chem. 1984, 48, 2994-2997.
https://doi.org/10.1021/jo00166a011

[12]. David-Cordonnier, M. H.; Hildebrand, M. P.; Baldeyrou, B.; Lansiaux, A.; Keuser, C.; Benzschawel, K.; Lemster, T.; Pindur, U. Eur. J. Med. Chem. 2007, 42, 752-771.
https://doi.org/10.1016/j.ejmech.2006.12.039

[13]. Burstein, E. S. US patent 20060252744 A1 (2006).

[14]. Balaure, P. C.; Costea, I.; Florin, I.; Draghici, C.; Enache, C. Rev. Roum. Chim. 2009, 54, 935-942.

[15]. Martinez, R.; Ruben, C.; Espinosa, R. C.; Toscano, R. A.; Cogordan, J. A.; Arellano, M. D. R.; Angeles, E.; Posada, M. D. R.; Maya, B.; Martine, L. J. Heterocyclic Chem. 1996, 33, 715-718.
https://doi.org/10.1002/jhet.5570330332

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).