European Journal of Chemistry

Synthesis, characterization and crystal structure of ethyl 4-(3-chloro benzamido)benzoate



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Aamer Saeed
Hummera Rafique
Ulrich Flörke

Abstract

The title compound was efficiently synthesized in two steps starting from esterification of 4-aminobenzoic acid followed by amidation with 3-chlorobenzoyl chloride in dry tetrahydrofuran. The structure was confirmed by spectroscopic data and elemental analysis. The molecular structure was determined from single crystal X-ray diffraction data. It crystallizes in the triclinic space group P-1 with Z = 2 and unit cell dimensions a = 5.2941(15) Å, b = 8.157(2) Å, c = 16.238(4) Å, α = 82.682(6)°, β = 84.481(6)°, γ = 80.100(6)° and V = 683.2(3) Å3.

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Saeed, A.; Rafique, H.; Flörke, U. Synthesis, Characterization and Crystal Structure of Ethyl 4-(3-Chloro benzamido)benzoate. Eur. J. Chem. 2010, 1, 289-290.

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References

[1]. Omar, F. A.; Mahfouz, N. M.; Rahman, M. A. Eur. J. Med. Chem. 1996, 31, 819-825.
doi:10.1016/0223-5234(96)83976-6

[2]. Amir, M.; Oberoi, A.; Alam, S. Indian J. Chem. 1999, 38B, 237-242.

[3]. Palaska, E.; Sahin, G.; Kelicen, P.; Durlu, N. T.; Altinok, G. Farmaco 2002, 57, 101-107.
doi:10.1016/S0014-827X(01)01176-4

[4]. Kumar, A.; Bansal, D.; Bajaj, K.; Sharma, S.; Archana, K.; Srivastava, V. K. Bioorg. Med. Chem. 2003, 11, 5281-5291.
doi:10.1016/S0968-0896(03)00529-7

[5]. Jackson, S.; DeGrado, W.; Dwivedi, A.; Parthasarathy, A.; Higley, A.; Krywko, J.; Rockwell, A.; Markwalder, J.; Wells, G.; Wexler, R.; Mousa, S.; Harlow, R. J. Am. Chem. Soc. 1994, 116, 3220-3230.
doi:10.1021/ja00087a007

[6]. Capdeville, R.; Buchdunger, E.; Zimmermann, J.; Matter, J. Nat. Rev. Drug Discovery. 2002, 1, 493-502.
doi:10.1038/nrd839
PMid:12120256

[7]. Manley, P. W.; Furet, P.; Bold, G.; Bruggen, J.; Mestan, J.; Meyer, T.; Schnell, C. R.; Wood, J. J. Med. Chem. 2002, 45, 5687-5693.
doi:10.1021/jm020899q
PMid:12477352

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