European Journal of Chemistry 2011, 2(4), 509-513 | doi: https://doi.org/10.5155/eurjchem.2.4.509-513.463 | Get rights and content






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Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety


Mahmoud Abdallah Mohamed (1) , Eman Kamal Ahmad Abdelall (2) , Yasser Hassan Zaki (3) , Abdou Osman Abdelhamid (4,*)

(1) Department of Textile, Faculty of Industrial Education, Beni-Suef University, Beni-Suef-62514, Egypt
(2) Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef-62514, Egypt
(3) Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef-62514, Egypt
(4) Department of Chemistry, Faculty of Science, Cairo University, Giza-12613, Egypt
(*) Corresponding Author

Received: 18 May 2011 | Revised: 07 Jun 2011 | Accepted: 16 Jun 2011 | Published: 31 Dec 2011 | Issue Date: December 2011

Abstract


pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine and pyrimido[1,2-a] benzimidazole derivatives were synthesized by reaction of sodium salt of 3-hydroxy-(1-pyridin-2-yl)prop-2-en-1-one or sodium salt of 3-hydroxy-1-(pyridin-3-yl)prop-2-en-1-one with different heterocyclic amines in piperidenium acetate. Also, 3-amino-6-(2-pyridyl)thieno[2,3-b]pyridine derivatives were synthesized via reaction of pyridine-2-thione with various halogenated compounds. The structures of the newly synthesized compounds were confirmed by elemental analysis, spectral data, X-ray and alternative synthetic routes whenever possible.

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Keywords


Pyridines; Thieno[2,3-b]pyridine; Pyrazolo[1,5-a]pyrimidine; Triazolo[1,5-a]pyrimidine; Pyrimido[1,2-a]benzimidazole; Piperidenium acetate

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DOI: 10.5155/eurjchem.2.4.509-513.463

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[1]. Sobhi Gomha, Sayed Ahmed, Abdou Abdelhamid
Synthesis and Cytotoxicity Evaluation of Some Novel Thiazoles, Thiadiazoles, and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones Incorporating Triazole Moiety
Molecules  20(1), 1357, 2015
DOI: 10.3390/molecules20011357
/


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Supporting information


The Supplementary Material for this article can be found online at: Supplementary files

How to cite


Mohamed, M.; Abdelall, E.; Zaki, Y.; Abdelhamid, A. Eur. J. Chem. 2011, 2(4), 509-513. doi:10.5155/eurjchem.2.4.509-513.463
Mohamed, M.; Abdelall, E.; Zaki, Y.; Abdelhamid, A. Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety. Eur. J. Chem. 2011, 2(4), 509-513. doi:10.5155/eurjchem.2.4.509-513.463
Mohamed, M., Abdelall, E., Zaki, Y., & Abdelhamid, A. (2011). Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety. European Journal of Chemistry, 2(4), 509-513. doi:10.5155/eurjchem.2.4.509-513.463
Mohamed, Mahmoud, Eman Kamal Ahmad Abdelall, Yasser Hassan Zaki, & Abdou Osman Abdelhamid. "Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety." European Journal of Chemistry [Online], 2.4 (2011): 509-513. Web. 4 Jul. 2020
Mohamed, Mahmoud, Abdelall, Eman, Zaki, Yasser, AND Abdelhamid, Abdou. "Synthesis of some new of thieno[2,3-b]pyridines, pyrazolo[1,5-a]pyrimidine, [1,2,4]triazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine and pyrimido[1,2-a]benzimidazole derivatives containing pyridine moiety" European Journal of Chemistry [Online], Volume 2 Number 4 (31 December 2011)

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DOI Link: https://doi.org/10.5155/eurjchem.2.4.509-513.463

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