OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS
A novel method for tizanidine hydrochloride determination in aqueous solution based on fluorescence quenching of functionalised CdS quantum dots as luminescent probes
Marwa Ahmed Fouad (1,*) , Ehab Farouk Elkady (2)
(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo-11562, Egypt
(2) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo-11562, Egypt
(*) Corresponding Author
Received: 14 Jul 2011 | Revised: 19 Aug 2011 | Accepted: 21 Aug 2011 | Published: 31 Mar 2012 | Issue Date: March 2012
A novel, sensitive and convenient method for the determination of tizanidine hydrochloride (TZD) based on the fluorescence quenching of thioglycolic acid-capped CdS quantum dots (TGA-CdS QDs) is proposed. Luminescent CdS semiconductor quantum dots modified by thioglycolic acid were synthesized from cadmium nitrate and sodium sulfide in alkaline aqueous solution. The modified CdS QDs are water-soluble, stable and highly luminescent. When TZD was added into the CdS QDs colloidal solution, the surface of CdS QDs generates the electrostatic interaction in aqueous medium, which induces the quenching of fluorescence emission at 518 nm upon excitation at 340 nm. Under the optimal conditions, the Stern-Volmer calibration plot of Fο/F against concentration of TZD was linear in the range of 3.0-18.0 μg/mL with a correlation coefficient of 0.9953. The detection limit was 1.35 μg/mL. The relative standard deviation for five determinations of 9 μg/mL TZD was 2.29%. The proposed method was successfully applied to commercial tablets with satisfactory results. The results were found to be in good agreement with those obtained by the reference method. The possible fluorescence quenching mechanism for the reaction is also discussed.
Links for Article
| | | | | | |
| | | | | | |
Article MetricsThis Abstract was viewed 822 times | PDF Article downloaded 378 times
. J. Shah, M. Rasul Jan, Tasmia, M. Yousaf
Cadmium Sulfide Quantum Dots as a Fluorescent Probe for Quantitative Determination of Cefixime
Journal of Applied Spectroscopy 83(2), 248, 2016
. Ramzia Ismail El-Bagary, Asmaa Ahmed El-Zaher, Ehab Farouk Elkady, Asmaa Abdelkerim Mandour
A novel method for determination of tinidazole and metronidazole in aqueous solutions based on fluorescence quenching of functionalized CdS quantum dots as luminescent probes
Future Journal of Pharmaceutical Sciences 4(2), 185, 2018
. Kaul, N.; Dhaneshwar, S. R.; Agrawal, H.; Kakad, A.; Patil, B. J. Pharm. Biomed. Anal. 2005, 37, 27-38.
. Sujatha, K.; Chitra, K.; Hettiarachchi, D. S.; Krishna, V. M.; Vasantha, J. Indian J. Pharm. Sci. 2003, 65, 519-520.
. Shankar, M. B.; Shah, D. A.; Geetha, M.; Mehta, F. A.; Mehta, R. S.; Bhatt, K. K. Indian J. Pharm. Sci. 2004, 66, 332-336.
. Lee, J.; Seo, J. H.; Kim, D. H. Analyst 2002, 127, 917-920.
. Mahadik, K. R.; Paradkar, A. R.; Agrawal, H.; Kaul, N. J. Pharm. Biomed. Anal. 2003, 33, 545-552.
. Qi, M.; Wang, P.; Wang, L. Anal. Chim. Acta. 2003, 478, 171-177.
. Gandhimathi, M.; Ravi, T. K.; Varghese, S. J. J. Pharm. Biomed. Anal. 2005, 37, 183-185.
. Battu, P. R. Int. J. ChemTech Res. 2009, 1, 499-501.
. Healzlewood, V.; Symoniw, P.; Maruff, P.; Eadie, M. J. Eur. J. Clin. Pharmacol. 1983, 25, 65-72.
. Peng, J.; Hu, X. J. Lumin. 2011, 131, 952-955.
. Gore, A. H.; Mote, U. S.; Tele, S. S.; Anbhule, P. V.; Rath, M. C.; Patil, S. R.; Kolekar, G. B. Analyst 2011, 136, 2606-2612.
. Dong, F.; Hu, K.; Han, H.; Liang. J. Microchim. Acta 2009, 165, 195-201.
. Winter, J. O.; Gomez, N.; Gatzert, S.; Schmidt, C. E.; Korgel, B. A. Colloids Surf. A: Physicochem. Eng. Aspects. 2005, 254, 147-157.
. Liu, M.; Xu, L.; Cheng, W.; Zeng, Y.; Yan, Z. Spectrochim. Acta Part A 2008, 70, 1198-1202.
. Liang, J. G.; Huang, S.; Zeng, D. Y.; He, Z. K.; Ji, X. H.; Ai, X. P.; Yang, X. H. Talanta 2006, 69, 126-130.
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.3.1.40-43.485
| | | | | | |
| | | | | |
Save to Zotero Save to Mendeley
European Journal of Chemistry 2012, 3(1), 40-43 | doi: https://doi.org/10.5155/eurjchem.3.1.40-43.485 | Get rights and content
- There are currently no refbacks.
© Copyright 2010 - 2020 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2020 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.