Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity

Sohail Anjum Shahzad; Muhammad Yar; Zulfiqar Ali Khan; Islam Ullah Khan; Syed Ali Raza Naqvi; Nasir Mahmood; Khalid Mohammed Khan

doi:10.5155/eurjchem.3.2.143-146.551

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Published: Jun 30, 2012

DOI: https://doi.org/10.5155/eurjchem.3.2.143-146.551

Keywords:

High yield, Hydrazides, Solvent free, Urease inhibition, Microwave-irradiation, Substituted-1, 3, 4-oxadiazole

Section

Research Article

Issue

Vol. 3 No. 2 (2012): June 2012

Dates

Received 2011-11-18
Accepted 2012-02-03
Published 2012-06-30

Sohail Anjum Shahzad

Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan

Muhammad Yar

Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore, 54000, Pakistan

Zulfiqar Ali Khan

Department of Chemistry, Government College University, Faisalabad, 38000, Pakistan

Islam Ullah Khan

Department of Chemistry, Government College University, Lahore, 54000, Pakistan

Syed Ali Raza Naqvi

Department of Chemistry, Government College University, Faisalabad, 38000, Pakistan

Nasir Mahmood

Department of Allied Sciences and Chemical Pathology, University of Health Sciences, Lahore, 54600, Pakistan

Khalid Mohammed Khan

Hussain Ibrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan

Abstract

An efficient solvent free microwave assisted synthesis of 5-substituted-1,3,4-oxadiazole-2(3H)-thiones (2a-2r) from hydrazides and carbon disulfide has been accomplished in good to excellent yield. The urease inhibition activity of the resulting compounds was investigated. Preliminary bioassay indicated that the compound 2j bearing 2-bromo substituent is the most active inhibitor exhibiting IC₅₀12.60 ± 0.92 μM.

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(1)

Shahzad, S. A.; Yar, M.; Khan, Z. A.; Khan, I. U.; Naqvi, S. A. R.; Mahmood, N.; Khan, K. M. Microwave-Assisted Solvent Free Efficient Synthesis of 1,3,4-Oxadiazole-2(3H)-Thiones and Their Potent in Vitro Urease Inhibition Activity. Eur. J. Chem. 2012, 3, 143-146.

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Supporting Agencies

The Organisation for the Prohibition of Chemical Weapons (OPCW), Netherland and Higher Education Commission (HEC) Pakistan (Project No. 1910 and under IPFP)

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