European Journal of Chemistry 2012, 3(3), 356-358 | doi: https://doi.org/10.5155/eurjchem.3.3.356-358.621 | Get rights and content






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Anticancer activity studies of some cyclic benzimidazole derivatives


Ali El-Shekeil (1,*) , Abeer Omer Obeid (2) , Sama Al-Aghbari (3)

(1) Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
(2) Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
(3) Chemistry Department, Faculty of Science, Sana’a University, 2463, Sana’a, Yemen
(*) Corresponding Author

Received: 23 Apr 2012 | Accepted: 17 Jun 2012 | Published: 30 Sep 2012 | Issue Date: September 2012

Abstract


New benzimidazole derivatives, namely, (N-(4-methoxyphenyl)methylene]-1H-benzimidazol-2-amine (2a), (N-(3,4-dimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2b), and (N-(3,4,5-trimethoxyphenyl)methylene]-1H-benzimidazol-2-amine (2c) were synthesized by reaction of a Schiff base with malononitrile in absolute ethanol. Structures of compounds have been confirmed by IR, 1H NMR and elemental analysis. Compounds 2a-c were screened for their in vitro anticancer potential using HeLa and PC3 cells. All compounds showed limited cytotoxicity except compound 2a that showed a moderate cytotoxic effect towards HeLa cells.

3_3_356_358_800


Keywords


PC3 cells; Hela cells; Cytotoxicity; Anti-cancer activity; Benzimidazole derivatives; 4-Amino-2-(3,4,5-trimethoxyphenyl)benzo[4,5]imidazo[1,2-a]pyrimidine-3-carbonitrile

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DOI: 10.5155/eurjchem.3.3.356-358.621

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Funding information


Sana’a University, Sana’a, Yemen

Citations

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Tetrahedron Letters  59(6), 554, 2018
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How to cite


El-Shekeil, A.; Obeid, A.; Al-Aghbari, S. Eur. J. Chem. 2012, 3(3), 356-358. doi:10.5155/eurjchem.3.3.356-358.621
El-Shekeil, A.; Obeid, A.; Al-Aghbari, S. Anticancer activity studies of some cyclic benzimidazole derivatives. Eur. J. Chem. 2012, 3(3), 356-358. doi:10.5155/eurjchem.3.3.356-358.621
El-Shekeil, A., Obeid, A., & Al-Aghbari, S. (2012). Anticancer activity studies of some cyclic benzimidazole derivatives. European Journal of Chemistry, 3(3), 356-358. doi:10.5155/eurjchem.3.3.356-358.621
El-Shekeil, Ali, Abeer Omer Obeid, & Sama Al-Aghbari. "Anticancer activity studies of some cyclic benzimidazole derivatives." European Journal of Chemistry [Online], 3.3 (2012): 356-358. Web. 5 Dec. 2020
El-Shekeil, Ali, Obeid, Abeer, AND Al-Aghbari, Sama. "Anticancer activity studies of some cyclic benzimidazole derivatives" European Journal of Chemistry [Online], Volume 3 Number 3 (30 September 2012)

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DOI Link: https://doi.org/10.5155/eurjchem.3.3.356-358.621

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