European Journal of Chemistry

Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography

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Published: Mar 31, 2013
DOI: https://doi.org/10.5155/eurjchem.4.1.58-60.678
Keywords:
Conformity, Optimization, Ketoprofen, Phosphate buffer, Validation method, High performance liquid chromatography
Section
Research Article
Issue
Vol. 4 No. 1 (2013): March 2013
Dates
Received 2012-09-14
Accepted 2012-10-06
Published 2013-03-31


Main Article Content

Tadjuddin Naid
Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
Wahyu Rizandi Syukur
Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
Amran Ilyas
Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
Seniwati Dali
Chemistry Department, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Makassar, 90245, Indonesia
Baharuddin Hamzah
Chemistry Education Study Program, Faculty of Teacher Training and Education, Tadulako University, Palu, 94118, Indonesia

Abstract

The study was conducted with the purpose to develop and validate a high performance liquid chromatography method with UV detector to determine ketoprofen content in tablet preparation using ethanol-phosphate buffer (pH = 6.0, 80:20, v:v). The method was validated toward parameters of accuracy, precision, linearity, selectivity, LOD and LOQ. The results obtained fulfill the validation requirement of the ketoprofen tablet in the form of LOD = 0.5302 ppm and LOQ = 1.7676 ppm.

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How to Cite
(1)
Naid, T.; Syukur, W. R.; Ilyas, A.; Dali, S.; Hamzah, B. Validation of Analysis Method for Determining Ketoprofen Concentration in Pharmaceutical Dosage Form Using High Performance Liquid Chromatography. Eur. J. Chem. 2013, 4, 58-60.

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References

[1]. Aznan, H. J.; Juli, S. Use of Anti-Inflammatory Non-Steroidal Rational at Tackling Rheumatic Pain. South Sumatera University Publishing, 2004.

[2]. Ferdiansyah, F. Behavior of Ketoprofen Diffusion through the Chitosan-CMC membrane. Bogor Agricultural Institute Publishing, 2009.
PMid:18651245

[3]. Epshtein, N. A. Pharm. Chem. J. 2005, 34(4), 212-228.

[4]. Qomariah, N. The Influence of an Tromethamine Organic amine base to the solubility of ketoprofen, Airlangga University Publishing, 2007.

[5]. Ermer, J. Method Validation in Pharmaceutical Analysis. Weinheim: Wiley-VCH Verlag GmbH & Co. KgaA, 2005.
http://dx.doi.org/10.1002/3527604685

[6]. Brown, P.; Deantonis, K. High Performance Liquid Chromatography, In. F. A., Settel (eds), Handbook or Instrumental Techniques for Analytical Chemistry, Prentice-Hall Inc., 1997.

[7]. Darnpanid, U. The effect of Phospholipid as Penetration Enhancer on Skin Permeation of Ketoprofen, Mahidol University Publishing, 2004.

[8]. Mallikarjuna, N. R.; Kondi, R. K.; Bagyalakshmi, J.; Ravi, T. K.; Ramakotaiah, M. Int. J. Res. Pharm. Sci. 2010, 1(2), 190-194.

[9]. Marcio, F.; Liberato, B. J.; Micheli, W.; Thiago, B.; Sergio, L. D. Acta Farm. 2006, 25 (1), 117-122.

[10]. World Health Organization. Validation of analytical Procedures Used in The examination of Pharmaceutical Materials, WHO Technical Report Series No. 823, 2007.

[11]. United States Pharmacopeia. The National Formulary 30th edition, The United States Pharmacopeia Convention, 1407, 2007.

[12]. Srinivasu, K.; Vankateswara, J. R.; Appala, N. R.; Mukkanti, K. E-J. Chem. 2011, 8(1), 453-456.

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