European Journal of Chemistry 2013, 4(1), 58-60 | doi: https://doi.org/10.5155/eurjchem.4.1.58-60.678 | Get rights and content






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Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography


Tadjuddin Naid (1) , Wahyu Rizandi Syukur (2) , Amran Ilyas (3) , Seniwati Dali (4) , Baharuddin Hamzah (5,*)

(1) Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
(2) Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
(3) Faculty of Pharmacy, Hasanuddin University, Makassar, 90245, Indonesia
(4) Chemistry Department, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Makassar, 90245, Indonesia
(5) Chemistry Education Study Program, Faculty of Teacher Training and Education, Tadulako University, Palu, 94118, Indonesia
(*) Corresponding Author

Received: 14 Sep 2012 | Accepted: 02 Nov 2012 | Published: 31 Mar 2013 | Issue Date: March 2013

Abstract


The study was conducted with the purpose to develop and validate a high performance liquid chromatography method with UV detector to determine ketoprofen content in tablet preparation using ethanol-phosphate buffer (pH = 6.0, 80:20, v:v). The method was validated toward parameters of accuracy, precision, linearity, selectivity, LOD and LOQ. The results obtained fulfill the validation requirement of the ketoprofen tablet in the form of LOD = 0.5302 ppm and LOQ = 1.7676 ppm.

4_1_58_60

Keywords


Conformity; Optimization; Ketoprofen; Phosphate buffer; Validation method; High performance liquid chromatography

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DOI: 10.5155/eurjchem.4.1.58-60.678

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How to cite


Naid, T.; Syukur, W.; Ilyas, A.; Dali, S.; Hamzah, B. Eur. J. Chem. 2013, 4(1), 58-60. doi:10.5155/eurjchem.4.1.58-60.678
Naid, T.; Syukur, W.; Ilyas, A.; Dali, S.; Hamzah, B. Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography. Eur. J. Chem. 2013, 4(1), 58-60. doi:10.5155/eurjchem.4.1.58-60.678
Naid, T., Syukur, W., Ilyas, A., Dali, S., & Hamzah, B. (2013). Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography. European Journal of Chemistry, 4(1), 58-60. doi:10.5155/eurjchem.4.1.58-60.678
Naid, Tadjuddin, Wahyu Rizandi Syukur, Amran Ilyas, Seniwati Dali, & Baharuddin Hamzah. "Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography." European Journal of Chemistry [Online], 4.1 (2013): 58-60. Web. 26 Jan. 2020
Naid, Tadjuddin, Syukur, Wahyu, Ilyas, Amran, Dali, Seniwati, AND Hamzah, Baharuddin. "Validation of analysis method for determining ketoprofen concentration in pharmaceutical dosage form using high performance liquid chromatography" European Journal of Chemistry [Online], Volume 4 Number 1 (31 March 2013)

DOI Link: https://doi.org/10.5155/eurjchem.4.1.58-60.678

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European Journal of Chemistry 2013, 4(1), 58-60 | doi: https://doi.org/10.5155/eurjchem.4.1.58-60.678 | Get rights and content

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