European Journal of Chemistry

Utility of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide in the synthesis of some heterocyclic nitrogen compounds

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Published: Jun 30, 2013
DOI: https://doi.org/10.5155/eurjchem.4.2.168-171.762
Keywords:
Isatine, Acetic acid, Phthalimide, Phenylisothiocyanate, Quinazoline-2, 4-dione, Tetrachlorophthalic anhydride
Section
Research Article
Issue
Vol. 4 No. 2 (2013): June 2013
Dates
Received 2013-03-01
Accepted 2013-03-08
Published 2013-06-30


Main Article Content

Mamdouh Adly Hassan
Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sinai University, 45518, Arish, Egypt
Maghrabi Ali Seleem
Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
Ahmed Mohamed Mosallem Younes
Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
Mohamed Mobark Taha
Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt
Abou-Bakr Haredi Abdel-Monsef
Chemistry Department, Faculty of Science, South Valley University, Qena, 83523, Egypt

Abstract

An efficient synthesis of (2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-acetic acid hydrazide (3) has been achieved and described. The obtained hydrazide (3) was used in building of some interesting heterocycles such as, triazole, oxadiazole, pyrazole, phthalazine, and indol-2-one rings at position 3. The structures of the obtained compounds were confirmed by IR, 1H NMR, 13C NMR, MS spectral and elemental analysis.

4_2_168_171

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Hassan, M. A.; Seleem, M. A.; Younes, A. M. M.; Taha, M. M.; Abdel-Monsef, A.-B. H. Utility of (2,4-Dioxo-1,4-Dihydro-2H-Quinazolin-3-Yl)-Acetic Acid Hydrazide in the Synthesis of Some Heterocyclic Nitrogen Compounds. Eur. J. Chem. 2013, 4, 168-171.

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