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Spectrofluorometric determination of linagliptin in bulk and in pharmaceutical dosage form
Ramzia Ismail El-Bagary (1) , Ehab Farouk Elkady (2) , Bassam Mahfouz Ayoub (3,*)
(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(2) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
(3) Pharmaceutical Chemistry Department, Faculty of Pharmacy, British University in Egypt, El-Sherouk City, Cairo 11837, Egypt
(*) Corresponding Author
Received: 04 Jun 2013 | Revised: 26 Jul 2013 | Accepted: 18 Aug 2013 | Published: 30 Jun 2014 | Issue Date: June 2014
Simple and precise spectrofluorometric method has been developed and validated for the determination of linagliptin (LNG) in the range of 10-110 μg/mL. The results obtained were of good precision and statistically compared to the reference method using one-way analysis of variance (ANOVA). The method developed was satisfactorily applied to the analysis of the pharmaceutical formulation and proved to be specific and accurate for the quality control of linagliptin in its pharmaceutical dosage form. The development of spectrofluorometric method for the determination of LNG was of interest as no such methods have been reported.
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DOI Link: https://doi.org/10.5155/eurjchem.5.2.380-382.845
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European Journal of Chemistry 2014, 5(2), 380-382 | doi: https://doi.org/10.5155/eurjchem.5.2.380-382.845 | Get rights and content
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