European Journal of Chemistry 2014, 5(2), 334-338 | doi: | Get rights and content


Synthesis and anti-tumor activities of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives

Sayed Abdelkader Ahmed (1) , Osama Mohamed Ahmed (2,*) , Abdou Osman Abdelhamid (3)

(1) Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514 Egypt
(2) Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt
(3) Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
(*) Corresponding Author

Received: 26 Aug 2013 | Revised: 02 Nov 2013 | Accepted: 13 Dec 2013 | Published: 30 Jun 2014 | Issue Date: June 2014


Condensation of 1H-1,2,4-triazol-5-amine with the appropriate sodium (E)-(2-oxocycloalkylidene)methanolate gave 7,8-dihydro-6H-cyclopenta[e][1,2,4]triazolo [1,5-a]pyrimidine, 6,7,8,9-tetrahydro-[1,2,4]triazolo[1,5-a]quinazoline, 7,8,9,10-tetra hydro-6H-cyclohepta[e][1,2,4]triazolo[1,5-a]pyrimidine and 6,7,8,9,10,11-hexahydro cycloocta[e][1,2,4]triazolo[1,5-a]pyrimidine. Structures of the newly synthesized compounds were elucidated via elemental analyses, spectral (IR, 1H NMR, 13C NMR, 2D NMR), and X-ray single crystal diffraction data. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines.


Cyclooctane; Cyclohexane; Cyclopentane; Antitumor activity; 1H-1,2,4-triazol-5-amine; Triazolo[5,1-a]pyrimidine

Full Text:

PDF /    /

DOI: 10.5155/eurjchem.5.2.334-338.910

Links for Article

| | | | | | |

| | | | | | |

Related Articles

Article Metrics

This Abstract was viewed 1150 times | PDF Article downloaded 513 times



[1]. Sobhi Gomha, Yasser Zaki, Abdou Abdelhamid
Utility of 3-Acetyl-6-bromo-2H-chromen-2-one for the Synthesis of New Heterocycles as Potential Antiproliferative Agents
Molecules  20(12), 21826, 2015
DOI: 10.3390/molecules201219803

[2]. Nadia A. Abdelriheem, Yasser H. Zaki, Abdou O. Abdelhamid
Synthesis of some new pyrazolo[1,5-a]pyrimidine, pyrazolo[5,1-c]triazine, 1,3,4-thiadiazole and pyridine derivatives containing 1,2,3-triazole moiety
Chemistry Central Journal  11(1), , 2017
DOI: 10.1186/s13065-017-0282-4

[3]. Majid Mokaber-Esfahani, Hossein Eshghi, Ali Shiri, Marzieh Akbarzadeh, Mahdi Mirzaei
Synthesis of [1,2,4]Triazolo[3,4-b]Pteridines as a Novel Class of Heterocyclic Compounds
Journal of Chemical Research  39(4), 216, 2015
DOI: 10.3184/174751915X14271341601550

[4]. Nadia Abdelriheem, Sayed Ahmad, Abdou Abdelhamid
Synthesis of some new Thieno[2,3-b]pyridines, Pyrimidino[4',5':4,5]thieno[2,3-b]pyridine and Pyridines Incorporating 5-Bromobenzofuran-2-yl Moiety
Molecules  20(1), 822, 2015
DOI: 10.3390/molecules20010822

[5]. Abdou O. Abdelhamid, Sobhi M. Gomha, Ahmad S. Shawali
Synthesis and Antimicrobial Evaluation of Some Novel Thiazole, 1,3,4-Thiadiazole and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine Derivatives Incorporating Pyrazole Moiety
HETEROCYCLES  91(11), 2126, 2015
DOI: 10.3987/COM-15-13319

[6]. Maksym Fizer, Mikhailo Slivka
Synthesis of [1,2,4]triazolo[1,5-a]pyrimidine (microreview)
Chemistry of Heterocyclic Compounds  52(3), 155, 2016
DOI: 10.1007/s10593-016-1851-5

[7]. Hassan M. Abdel-aziz, Sobhi M. Gomha, Abdelaziz A. El-Sayed, Yahia Nasser Mabkhot, Abdulrhman Alsayari, Abdullatif Bin Muhsinah
Facile synthesis and antiproliferative activity of new 3-cyanopyridines
BMC Chemistry  13(1), , 2019
DOI: 10.1186/s13065-019-0652-1

[8]. Pankaj Kumar Singh, Shalki Choudhary, Aanchal Kashyap, Himanshu Verma, Swati Kapil, Manoj Kumar, Mohit Arora, Om Silakari
An exhaustive compilation on chemistry of triazolopyrimidine: A journey through decades
Bioorganic Chemistry  88, 102919, 2019
DOI: 10.1016/j.bioorg.2019.102919


[1]. Navarro, J. A. R.; Salas, J. M.; Romero, M. A.; Vilaplana, R.; Faure, R. J. Med. Chem. 1998, 41, 332-338.

[2]. Magan, R.; Marin, C.; Salas, J. M.; Perez, M. B.; Rosales, M. J.; Moreno, M. S. Mem. Inst. Oswaldo. Cruz. Rio de Janeiro 2004, 99, 651-656.

[3]. Magan, R.; Marin, C.; Rosales, M. J.; Salas, J. M.; Sanchez-Moreno, M. Pharmacology 2005, 73, 41-48.

[4]. Traxler, P. M.; Furet, P.; Mett, H.; Buchdunger, E.; Meyer, T.; Lydon, N. J. Med. Chem. 1996, 39, 2285-2292.

[5]. Rusinov, V. L.; Petrov, A. Y.; Pilicheva, T. L.; Chupakhin, O. N.; Kovalev, G. V.; Komina, E. R. Khim. Farm. Zh. 1986, 20, 178-182.

[6]. Lauria, A.; Diana, P.; Barraja, P.; Montalbano, A.; Cirrinicione, G.; Dattolo, G.; Almerico, A. M. Tetrahedron 2002, 58, 9723-9727.

[7]. Ram, V. J.; Upadhyay, D. N. Indian J. Chem. 1999, 38B, 1173-1177.

[8]. Ram, V. J.; Singha, U. K.; Guru, P. Y. Eur. J. Med. Chem. 1990, 25, 533-538.

[9]. Nakamura, H.; Hosoi, Y.; Fukawa, J. Jpn. Kokai Pat. 03, 10, 245 (1991); Chem Abstr. 1991, 115, 266657f.

[10]. Barthelemy, G.; Hallot, A.; Vallat, J. N. Fr. Pat. 2, 459, 834 (1985); Chem Abstr. 1985, 103, 71335u.

[11]. Zhao, X.; Zhao, Y.; Guo, S.; Song, H.; Wang, D.; Gong, P. Molecules 2007, 12, 1136-1146.

[12]. Touil, S.; Zantour, H. J. Soc. Chim. Tunis. 1999, 4(6), 529-535.

[13]. Ahmed, S. A.; Hussein, A. M.; Hozayena, W. G. M.; El-Ghandour, A. H. H.; Abdelhamid, A. O. J. Heterocycl Chem. 2007, 44, 803-810.

[14]. Vichai, V.; Kirtikara, K. Nat. Protoc. 2006, 1, 1112-1116.

[15]. Ahmed, O. M.; Mohamed, A. M.; Ahmed, R. R.; Ahmed, S. A. Eur. J. Med. Chem. 2009, 44, 3519-3523.

[16]. Hussein, A. M.; Ahmed, O. M. Bioorgan. Med. Chem. 2010, 18, 2639-2644.

[17]. Zhang, N.; Ayral-Kaloustian, S.; Nguyen, T.; Afragola, J.; Hernandez, R.; Lucas, J.; Gibbons, J.; Beyer, C. J. Med. Chem. 2007, 50, 319-327.

How to cite

Ahmed, S.; Ahmed, O.; Abdelhamid, A. Eur. J. Chem. 2014, 5(2), 334-338. doi:10.5155/eurjchem.5.2.334-338.910
Ahmed, S.; Ahmed, O.; Abdelhamid, A. Synthesis and anti-tumor activities of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives. Eur. J. Chem. 2014, 5(2), 334-338. doi:10.5155/eurjchem.5.2.334-338.910
Ahmed, S., Ahmed, O., & Abdelhamid, A. (2014). Synthesis and anti-tumor activities of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives. European Journal of Chemistry, 5(2), 334-338. doi:10.5155/eurjchem.5.2.334-338.910
Ahmed, Sayed, Osama Mohamed Ahmed, & Abdou Osman Abdelhamid. "Synthesis and anti-tumor activities of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives." European Journal of Chemistry [Online], 5.2 (2014): 334-338. Web. 11 Jul. 2020
Ahmed, Sayed, Ahmed, Osama, AND Abdelhamid, Abdou. "Synthesis and anti-tumor activities of new [1,2,4]triazolo[1,5-a]pyrimidine derivatives" European Journal of Chemistry [Online], Volume 5 Number 2 (30 June 2014)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item

DOI Link:

| | | | | | |

| | | | | |

Save to Zotero Save to Mendeley

European Journal of Chemistry 2014, 5(2), 334-338 | doi: | Get rights and content


  • There are currently no refbacks.

Copyright (c)

© Copyright 2010 - 2020  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2020 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.

hatay escort hatay escort corlu escort corum escort burgaz escort giresun escort aydin escort ordu escort erzincan escort hatay escort sivas escort rize escort edirne escort aksaray escort kibris escort isparta escort erzurum escort tekirdag escort usak escort urfa escort kastamonu escort kibris escort manisa escort giresun escort urfa escort nevsehir escort sivas escort yalova escort ordu escort hatay escort yalova escort amasya escort kayseri escort ordu escort maras escort canakkale escort yalova escort balikesir escort manisa escort urfa escort mugla escort trabzon escort bolu escort corlu escort diyarbakir escort isparta escort kutahya escort elazig escort erzurum escort sakarya escort afyon escort kutahya escort konya escort agri escort cesme escort sinop escort sivas escort konya escort kibris escort adapazari escort luleburgaz escort adana escort kibris escort rize escort sakarya escort alanya escort isparta escort burdur escort konya escort bitlis escort canakkale escort sivas escort amasya escort mus escort aydin escort van escort yalova escort kastamonu escort mardin escort bolu escort afyon escort sakarya escort isparta escort tokat escort trakya escort bayburt escort urfa escort mardin escort