European Journal of Chemistry

Application of a multi-component cyclocondensation to develop a bioactive molecular scaffold

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Published: Mar 31, 2016
DOI: https://doi.org/10.5155/eurjchem.7.1.135-136.1360
Keywords:
CNS, 5-HT6, Antagonist, Benzazepine, Furanoquinoline, Cyclocondensation
Section
Short Communication
Issue
Vol. 7 No. 1 (2016): March 2016
Dates
Received 2015-11-09
Accepted 2015-12-13
Published 2016-03-31


Main Article Content

Sankar Chatterjee
Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA

Abstract

A molecular scaffold containing a furanoquinoline motif that offered a unique molecular architecture for 5-hydroxytryptamine 6 receptor antagonism was generated by a multi-component cyclization reaction.


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Chatterjee, S. Application of a Multi-Component Cyclocondensation to Develop a Bioactive Molecular Scaffold. Eur. J. Chem. 2016, 7, 135-136.

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References

[1]. Benhamu, B.; Martiin-Fontecha, M.; Vazquez-Villa, H.; Pardo, L.; Lopez-Rodriguez, M. L. J. Med. Chem. 2014, 57, 7160-7181.
http://dx.doi.org/10.1021/jm5003952

[2]. Ramirez, M. J. Alzheimer's Res. Ther. 2013, 5(15), 1-8.

[3]. Wesolowska, A. Pharmacol. Rep. 2010, 62, 564-567.
http://dx.doi.org/10.1016/S1734-1140(10)70315-7

[4]. Ly, S.; Pishadari, B.; Lok, L. L.; Hajos, M.; Kocsis, B. ACS Chem. Neurosci. 2013, 4, 191-199.
http://dx.doi.org/10.1021/cn300184t

[5]. Rosse, G.; Schaffhauser, H. Curr. Top. Med. Chem. 2010, 10, 207-221.
http://dx.doi.org/10.2174/156802610790411036

[6]. Hostetler, G.; Dunn, D.; McKenna, B. A.; Kopec, K.; Chatterjee, S. Chem. Bio. Drug Des. 2014, 83, 149-153.
http://dx.doi.org/10.1111/cbdd.12240

[7]. Hostetler, G.; Dunn, D.; McKenna, B. A.; Kopec, K.; Chatterjee, S. Chem. Bio. Drug Des. 2014, 83, 666-669.
http://dx.doi.org/10.1111/cbdd.12279

[8]. Ravindranath, N.; Ramesh, C.; Reddy, M. R.; Das, B. A. Chem. Lett. 2003, 32, 222-223.
http://dx.doi.org/10.1246/cl.2003.222

[9]. DaSilva, B. H. S. T.; Martins, L. M.; Silva-Filho, L. C. Synlett. 2012, 23, 1973-1977.
http://dx.doi.org/10.1055/s-0032-1316587

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