European Journal of Chemistry

Recent advance in direct sp3 carbon-hydrogen bond functionalizations

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Published: Jun 30, 2016
DOI: https://doi.org/10.5155/eurjchem.7.2.248-270.1412
Keywords:
Metal-free, C-H bond activation, C-C bond formation, Transition-metal-catalyzed, C-heteroatom bond formation, Csp3-H bond functionalization
Section
Review Article
Issue
Vol. 7 No. 2 (2016): June 2016
Dates
Received 2016-02-20
Accepted 2016-03-19
Published 2016-06-30


Main Article Content

Xiao-Hua Cai
National School of Medicine, Guizhou Minzhu University, Guiyang 550025, China
Jun Jin
National School of Medicine, Guizhou Minzhu University, Guiyang 550025, China
Bing Xie
National School of Medicine, Guizhou Minzhu University, Guiyang 550025, China

Abstract

Direct and selective carbon-hydrogen bond functionalization has attracted enormous attention because it provides more efficient strategies for preparing valuable functional molecules from easily available substrates. Significant and exciting developments in functionalization of un-activation Csp3-H bonds have continuously been made over the past few decades. This review mainly summarizes recent advances on direct Csp3-H bond functionalization for the formation of C-C and C-heteroatom bond under transition-metal-catalysed and metal-free conditions.


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Cai, X.-H.; Jin, J.; Xie, B. Recent Advance in Direct Sp3 Carbon-Hydrogen Bond Functionalizations. Eur. J. Chem. 2016, 7, 248-270.

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Supporting Agencies

The National Natural Science Foundation of China (21562016), the Natural Science Foundation of the Guizhou Science and Technology Depart-ment (JZ [2014]2010) and the Science and Technology Planing Project of Guiyang city [(2012204)23], China.
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