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Synthesis and antimicrobial activity of 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane
Leila Lefrada (1,*)
, Randolf Köhn (2) , Souhila Malki (3) , Wissam Mazouz (4) , Ahcene Bouchemma (5) , Meriem Hadjem (6) (1) Laboratory of Applied Chemistry and Materials Technology University Larbi Ben M’hidi of Oum El Bouaghi, 04000, Algeria
(2) Department of Chemistry University of Bath, Bath, BA2 7AY, United Kingdom
(3) Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(4) Department of Biology, Faculty of Sciences, University Badji Mokhtar, 2300 Annaba, Algeria
(5) Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(6) Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
(*) Corresponding Author
Received: 30 Dec 2016 | Revised: 21 Jan 2017 | Accepted: 22 Jan 2017 | Published: 31 Mar 2017 | Issue Date: March 2017
Abstract
This work describes the synthesis, structural characterization and antibacterial activities of 1,3,5-triazacyclohexane type of new compound 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane. The new triazacyclohexanes (R3TAC) with mixed aryl and alkyl N-substituents are synthesized by the reaction of a 1:2 mixture of 4-iodoaniline and n-butylamine with formalin. The synthesized compounds were characterized by spectral analysis IR, 1H NMR and 13C NMR. The compound was screened for it’s antibacterial activity against Gram-positive and Gram-negative bacteria by the diffusion method on agar medium.
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DOI: 10.5155/eurjchem.8.1.82-84.1537
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Funding information
Laboratory of Applied Chemistry and Materials Technology of the University Larbi Ben M’hidi of Oum El Bouaghi, Research Fund (Project No: E03020130036), Algeria.
Citations
[1]. Amel Ferhati, Achene Bouchemma, Mustapha Bouhenguel, Leila Lefrada, Assia Sid
Synthesis and characterization of 1,3-bis(2-fluorophenyl)-5-pentyl-1,3,5-triazinane
European Journal of Chemistry 8(1), 18, 2017
DOI: 10.5155/eurjchem.8.1.18-19.1510
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DOI Link: https://doi.org/10.5155/eurjchem.8.1.82-84.1537
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European Journal of Chemistry 2017, 8(1), 82-84 | doi: https://doi.org/10.5155/eurjchem.8.1.82-84.1537 | Get rights and content
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