European Journal of Chemistry

Structural characterization, biological evaluation and DNA interaction of some potential drugs based on bifunctional aldehyde functionality

Article Sidebar

PDF CIF FILE CIF FILE CIF FILE
Published: Sep 30, 2017
DOI: https://doi.org/10.5155/eurjchem.8.3.195-202.1576
Keywords:
Hyperchromism, DNA damaging assay, Bifunctional aldehyde, Chemotherapeutic agent, Pharmacological activities, Bifunctional aldehyde-DNA interaction
Section
Research Article
Issue
Vol. 8 No. 3 (2017): September 2017
Dates
Received 2017-04-21
Accepted 2017-06-05
Published 2017-09-30


Main Article Content

Mehwish Naz
Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Zareen Akhter
Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Ayesha Zaka
Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Bushra Mirza
Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Vickie McKee
Department of Chemical Sciences, Dublin City University, Glasnevin, Dublin, 9, Ireland
Ehsan Ullah
Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Michael Bolte
Institut für Anorganische Chemie, Johann Wolfgang Goethe-Universität, Frankfurt/Main, D-60438, Germany

Abstract

Recent work aimed at evaluating the possibility of enhancing biological activities by synthetically modifying bifunctional aldehyde structures. In this article, two series of bifunctional aldehydes were synthesized, structurally characterized (M-1A, M-1C and M-2A) using single crystal X-ray diffraction analysis. Several pharmacological properties like cytotoxic, antifungal, antibacterial, antioxidant and antitumor activities were also evaluated. In addition, bifunctional aldehyde-DNA interaction assay was examined by UV-Vis spectroscopy which revealed the DNA damaging behaviour of these aldehydes. The results of UV-Vis spectroscopy were supported by DNA damaging assay. The overall results reveal that bifunctional aldehyde moiety could be used as potential drug candidates.


icon graph This Abstract was viewed 1617 times | icon graph Article PDF downloaded 819 times icon graph Article CIF FILE downloaded 0 times icon graph Article CIF FILE downloaded 0 times icon graph Article CIF FILE downloaded 0 times

How to Cite
(1)
Naz, M.; Akhter, Z.; Zaka, A.; Mirza, B.; McKee, V.; Ullah, E.; Bolte, M. Structural Characterization, Biological Evaluation and DNA Interaction of Some Potential Drugs Based on Bifunctional Aldehyde Functionality. Eur. J. Chem. 2017, 8, 195-202.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Wang, Q.; Bao, L.; Jia, C.; Li, M.; Li, J. J.; Lu, X. BMC Biotechn. 2017, 17(1), 31, pp. 1-9.

[2]. Ebada, M. E. J. Pharmacol. Clin. Res. 2017, 2(2), 555585, pp. 1-4.

[3]. Sterner, O.; Carter, R. E.; Nilsson, L. M. Mut. Res. Genetic Toxicol. 1987, 188(3), 169-174.
https://doi.org/10.1016/0165-1218(87)90086-3

[4]. Cimino, G.; De Rosa, S.; De Stefano, S.; Sodano, G.; Villani, G. Science 1983, 219(4589), 1237-1238.
https://doi.org/10.1126/science.219.4589.1237

[5]. Rashidi, M. R.; Soltani, S. Exp. Opinion Drug Discov. 2017, 12(3), 305-316.
https://doi.org/10.1080/17460441.2017.1284198

[6]. Abe, M.; Ozawa, Y.; Uda, Y.; Yamada, F.; Morimitsu, Y.; Nakamura, Y.; Osawa, T. Biosci., Biotech. Biochem. 2004, 68(7), 1601-1604.
https://doi.org/10.1271/bbb.68.1601

[7]. Fraud, S.; Maillard, J. Y.; Russell, A. D. J. Hosp. Inf. 2001, 48(3), 214-221.
https://doi.org/10.1053/jhin.2001.1009

[8]. Kubo, I.; Himejima, M. Experientia 1992, 48(11-12), 1162-1164.
https://doi.org/10.1007/BF01948015

[9]. Anke, H.; Sterner, O. Planta Medica 1991, 57(4), 344-346.
https://doi.org/10.1055/s-2006-960114

[10]. Hobro, A. J.; Smith, N. I. Vib. Spectrosc. 2017, 91, 31-45.
https://doi.org/10.1016/j.vibspec.2016.10.012

[11]. Dvonch, W.; Fletcher, H.; Gregory, F. J.; Healy, E. M. H.; Warren, G. H.; Alburn, H. E. Cancer Res. 1966, 26(11), 2386-2389.

[12]. Giraldi, T.; Goddard, P. M; Nisi, C.; Sigon, F. J. Pharm. Sci. 1980, 69(1), 97-98.
https://doi.org/10.1002/jps.2600690129

[13]. Billman, J. H.; Tonnis, J. A. J. Pharm. Sci. 1971, 60(8), 1188-1192.
https://doi.org/10.1002/jps.2600600815

[14]. Minotti, G.; Menna, P.; Salvatorelli, E.; Cairo, G.; Gianni, L. Pharmacolog. Rev. 2004, 56(2), 185-229.
https://doi.org/10.1124/pr.56.2.6

[15]. Jacobs, A. T.; Marnett, L. J. Acc. Chem. Res. 2010, 43(5), 673-683.
https://doi.org/10.1021/ar900286y

[16]. Nadkarni, D. V.; Sayre, L. M. Chem. Res. Toxicol. 1995, 8(2), 284-291.
https://doi.org/10.1021/tx00044a014

[17]. Brooks, P. J.; Theruvathu, J. A. Alcohol 2005, 35(3), 187-193.
https://doi.org/10.1016/j.alcohol.2005.03.009

[18]. Voulgaridou, G. P.; Anestopoulos, I.; Franco, R.; Panayiotidis, M. I.; Pappa, A. Mut. Res. / Fundam. Mol. Mechan. Mutagen. 2011, 711(1), 13-27.
https://doi.org/10.1016/j.mrfmmm.2011.03.006

[19]. Li, C. H.; Chang, T. C. J. Polymer Sci. A: Polymer Chem. 1991, 29(3), 361-367.
https://doi.org/10.1002/pola.1991.080290309

[20]. Kaya, I.; Koyuncu, S.; Culhaoglu, S. Polymer 2008, 49(3), 703-714.
https://doi.org/10.1016/j.polymer.2007.12.010

[21]. Gul, A.; Akhter, Z.; Siddiq, M.; Sarfraz, S.; Mirza, B. Macromolecules 2013, 46(7), 2800-2807.
https://doi.org/10.1021/ma400192u

[22]. Nawaz, H.; Akhter, Z.; Yameen, S.; Siddiqi, H. M.; Mirza, B.; Rifat, A. J. Organometal. Chem. 2009, 694(14), 2198-2203.

[23]. Sultan, M. T.; Butt, M. S.; Anjum, F. M.; Jamil, A.; Akhtar, S.; Nasir, M. Pak. J. Bot. 2009, 41(3), 1321-1330.

[24]. Oliveira-Brett, A. M.; Piedade, J. A. P.; Silva, L. A.; Diculescu, V. C. Anal. Biochem. 2004, 332(2), 321-329.
https://doi.org/10.1016/j.ab.2004.06.021

[25]. Oliveira-Brett, A. M.; Diculescu, V.; Piedade, J. A. P. Bioelectrochem. 2002, 55(1), 61-62.
https://doi.org/10.1016/S1567-5394(01)00147-5

[26]. Mclaughlin, J. L.; Rogers, L. L.; Anderson, J. E. Drug Infor. J. 1998, 32(2), 513-524.
https://doi.org/10.1177/009286159803200223

[27]. Shabbir, M.; Akhter, Z.; Ashraf, A. R.; Bolte, M.; Wahid, S.; Mirza, B. Eur. J. Chem. 2017, 8(1), 46-51.
https://doi.org/10.5155/eurjchem.8.1.46-51.1535

[28]. Ahmad, M. S.; Hussain, M.; Hanif, M.; Ali, S.; Qayyum, M.; Mirza, B. Chem. Biol. Drug Design 2008, 71(6), 568-576.
https://doi.org/10.1111/j.1747-0285.2008.00668.x

[29]. Sheldrick, G. M. Acta Cryst. A 2008, 64, 112-122.
https://doi.org/10.1107/S0108767307043930

[30]. Sheldrick, G. M. Acta Cryst. C 2015, 71, 3-8.
https://doi.org/10.1107/S2053229614024218

[31]. Gilles, M.; Zhao, J.; An, M.; Agboola S. Food Chem. 2010, 119, 731-737.
https://doi.org/10.1016/j.foodchem.2009.07.021

[32]. Anke, H.; Sterner, O. Planta Medica 1991, 57(4), 344-346.
https://doi.org/10.1055/s-2006-960114

[33]. Allouche, N.; Apel, C.; Martin, M. T.; Dumontet, V.; Gueritte, F.; Litaudon, M. Phytochem. 2009, 70(4), 546-553.
https://doi.org/10.1016/j.phytochem.2009.01.012

[34]. Lunde, C. S.; Kubo, I. Antimicrob. Agent. Chemother. 2000, 44(7), 1943-1953.
https://doi.org/10.1128/AAC.44.7.1943-1953.2000

[35]. Ryu, D. D.; Nam, D. H. Biotechn. Progr. 2000, 16(1), 2-16.
https://doi.org/10.1021/bp088059d

[36]. Oliveira-Brett, A. M.; Diculescu, V.; Piedade, J. A. P. Bioelectrochem. 2002, 55(1), 61-62.
https://doi.org/10.1016/S1567-5394(01)00147-5

[37]. Li, Q.; Yang, P.; Wang, H.; Guo, M. J. Inorg. Biochem. 1996, 64(3), 181-195.
https://doi.org/10.1016/0162-0134(96)00039-6

Supporting Agencies

Most read articles by the same author(s)

Most read articles by the same author(s)

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).