European Journal of Chemistry

Spectroscopic and molecular docking elucidation to binding characteristics of bovine serum albumin with bupropion an aminoketone-medication for nicotine addiction

Crossmark


Main Article Content

Manjushree Makegowda
Revanasiddappa Hosakere Doddarevanna

Abstract

One of the highly soluble protein presents in circulatory system of bovine body is bovine serum albumin (BSA). Bupropion hydrochloride (BRN) served to treat prime smoking cessation and disorder due to depressive. BRN binding to BSA was studied by molecular docking and lots of spectroscopic (UV-vis, emission, synchronous, 3D fluorescence, CD and FT-IR) methods at pH = 7.40. Static quenching with strong binding was obtained for BSA-BRN system by forming complex. Secondary structures, conformations and microenvironments of BSA were altered after BRN interaction. Distance between BRN and BSA was also achieved. Biologically active metal ions (Cu2+, Ca2+, Mg2+, Fe2+ and Zn2+) were also influenced on the BSA-BRN complex. Bonds of hydrogen and Van der Waals were major binding forces to stabilize BSA-BRN complex at site I (IIA) of BSA. Hence, binding of BRN to transport protein (BSA) is of prominent importance and these findings could be helpful for BRN pharmacology and potential clinical research.


icon graph This Abstract was viewed 1211 times | icon graph Article PDF downloaded 548 times icon graph Article SUPPLEMENTARY FILE downloaded 0 times

How to Cite
(1)
Makegowda, M.; Doddarevanna, R. H. Spectroscopic and Molecular Docking Elucidation to Binding Characteristics of Bovine Serum Albumin With Bupropion an Aminoketone-Medication for Nicotine Addiction. Eur. J. Chem. 2019, 10, 146-155.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. Bupropion hydrochloride, RxList. https://www.rxlist.com/ wellbutrin-xl-drug.htm/ , 2018 (accessed 06 September 2018).

[2]. Bupropion hydrochloride, WebMD. https://www.webmd.com/ drugs/2/drug-13507-7155/bupropion-hcl-oral/bupropion-extended-release-antidepressant-oral/details/, 2018 (accessed 06 September 2018).

[3]. Zhang, G.; Wang, L.; Fu, P.; Hu, M. Spectrochim. Acta A 2011, 82, 424-431.
https://doi.org/10.1016/j.saa.2011.07.073

[4]. Zhang, Q.; Fu, X.; Garcia Martín, J. F. Ultrason. Sonochem. 2017, 37, 405-413.
https://doi.org/10.1016/j.ultsonch.2017.01.031

[5]. Manjushree, M.; Revanasiddappa, H. D. J. Mol. Liq. 2017, 237, 23-37.

[6]. Sajid Ali, M.; Al-Lohedan, H. J. Mol. Liq. 2017, 236, 232-240.
https://doi.org/10.1016/j.molliq.2017.04.020

[7]. Skrt, M.; Benedik, E.; Podlipnik, C.; Ulrih, N. P. J. Food. Chem. 2012, 135, 2418-2424.
https://doi.org/10.1016/j.foodchem.2012.06.114

[8]. Majorek, K. A.; Porebski, P. J.; A. Dayal, M. D.; Zimmerman, K.; Jablonska, A. J.; Stewart, M.; Chruszcz, W. J. Mol. Immunol. 2012, 52, 174-182.
https://doi.org/10.1016/j.molimm.2012.05.011

[9]. Ojha, B.; Das, G. J. Phys. Chem. 2010, 114, 3979-3986.
https://doi.org/10.1021/jp907576r

[10]. Manjushree, M.; Revanasiddappa, H. D. Spectrochim. Acta A 2019, 209, 264-273.

[11]. Lakowicz, J. R. Principles of Fluorescence Spectroscopy. Third ed. Springer, New York, 2006.
https://doi.org/10.1007/978-0-387-46312-4

[12]. Rosenheck, K.; Doty, P. Proc. Natl. Acad. Sci. U. S. A. 1961, 47, 1775-1785.
https://doi.org/10.1073/pnas.47.11.1775

[13]. Zhou, K.; Pan, D.; Lou, Y.; Shi, J. J. Mol. Recognit. 2018, e2716.
https://doi.org/10.1002/jmr.2716

[14]. Sun, Z.; Xu, H.; Cao, Y.; Wang, F.; Mi, W. J. Mol. Liq. 2016, 219, 405-410.
https://doi.org/10.1016/j.molliq.2016.03.040

[15]. Lakowicz, J. R.; Weber, G. Biochemistry 1973, 12, 4161-4170.
https://doi.org/10.1021/bi00745a020

[16]. Chaves, O. A.; Silva, V. A.; Sant'Anna, C. M. R.; Ferreira, A. B. B.; Ribeiro, T. A. N.; Carvalho, M. G.; Cesarin-Sobrinho, D.; Netto-Ferreira, J. C. J. Mol. Struct. 2017, 1128, 606-611.
https://doi.org/10.1016/j.molstruc.2016.09.036

[17]. Wei, X. L.; Xiao, J. B.; Wang, Y.; Bai, Y. Spectrochim. Acta A. 2010, 75, 299-304.
https://doi.org/10.1016/j.saa.2009.10.027

[18]. Ross, P. D.; Subramanian, S. Biochemistry 1981, 20, 3096-3102.
https://doi.org/10.1021/bi00514a017

[19]. Xi, J. Q.; Fan, L. J. Therm. Anal. Calorim. 2010, 102, 217-223.
https://doi.org/10.1007/s10973-010-0792-y

[20]. Katrahalli, U.; Jaldappagari, S.; Kalanur, S. J. Lumin. 2010, 130, 211-216.
https://doi.org/10.1016/j.jlumin.2009.07.033

[21]. Yang, P.; Gao, F. The Principle of Bioinorganic Chemistry. Science Press: Beijing, China, 2002, pp. 349.

[22]. Förster, T. Delocalized excitation and excitation transfer, O. Sinanoglu (Ed.), Modern Quantum Chemistry. Istanbul Lectures 3, Academic Press, New York/London, 1965, pp. 93-137.

[23]. Zhang, Q.; Ni, Y.; Kokot, S. J. Pharm. Biomed. Anal. 2010, 52, 280-288.
https://doi.org/10.1016/j.jpba.2010.01.006

[24]. Molina-Bolívar, J. A.; Galisteo-González, F.; Ruiz, C. C.; Donnell, M. M.; Parra, A. J. Mol. Liq. 2015, 208, 304-313.
https://doi.org/10.1016/j.molliq.2015.04.050

[25]. Ni, Y.; Zhu, R.; Kokot, S. Analyst 2011, 136, 4794-4801.
https://doi.org/10.1039/c1an15550d

[26]. Wang, N.; Ye, L.; Yan, F.; Xu, R. Int. J. Pharm., 2008, 351, 55-60.
https://doi.org/10.1016/j.ijpharm.2007.09.016

[27]. Xiao, J. B.; Chen, J. W.; Cao, H.; Ren, F. L.; Yang, C. S.; Chen, Y.; Xu, M. J. Photochem. Photobiol. A 2007, 191, 222-227.
https://doi.org/10.1016/j.jphotochem.2007.04.027

TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).