European Journal of Chemistry

Study of some alcohol amounts in commercial alcoholic disinfectant solutions using gas chromatography with flame ionization detection

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Masoumeh Darbanian
Azizollah Nezhadali
Vafa Baradaran Rahimi

Abstract

A simple solvent extraction method was used to analyze alcohol-based hand rubs (ABHRs) using gas chromatography with a flame ionization detector. 79 samples including 68 liquid and 11-gelled ABHRs were analyzed in the Food and Drug Laboratories Research Center of Mashhad, Iran. 17 samples had methanol, 50 samples had the correct percentage of alcohol (60-80%), and 12 samples had the incorrect percentage of alcohol (<60%). The RSD% of methanol, ethanol, and isopropanol were as 2.28, 2.18, and 1.52, respectively. The relative recoveries for methanol, ethanol, and isopropanol were 102.5, 97.8, and 114, respectively. All experiments were repeated three times. The limit of detection and the limit of quantification for methanol, ethanol, and isopropanol were obtained as 0.22, 0.24, 0.10 (%) and 0.71, 0.82, 0.68 (%), respectively.


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Darbanian, M.; Nezhadali, A.; Rahimi, V. B. Study of Some Alcohol Amounts in Commercial Alcoholic Disinfectant Solutions Using Gas Chromatography With Flame Ionization Detection. Eur. J. Chem. 2022, 13, 279-283.

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References

[1]. Trampuz, A.; Widmer, A. F. Hand hygiene: a frequently missed life saving opportunity during patient care. Mayo Clin. Proc. 2004, 79, 109-116.
https://doi.org/10.4065/79.1.109

[2]. Bloomfield, S. F.; Aiello, A. E.; Cookson, B.; O'Boyle, C.; Larson, E. L. The effectiveness of hand hygiene procedures in reducing the risks of infections in home and community settings including handwashing and alcohol-based hand sanitizers. Am. J. Infect. Control 2007, 35, S27-S64.
https://doi.org/10.1016/j.ajic.2007.07.001

[3]. Tse, T. J.; Nelson, F. B.; Reaney, M. J. T. Analyses of commercially available alcohol-based hand rubs formulated with compliant and non-compliant ethanol. Int. J. Environ. Res. Public Health 2021, 18, 3766.
https://doi.org/10.3390/ijerph18073766

[4]. Winnefeld, M.; Richard, M. A.; Drancourt, M.; Grob, J. J. Skin tolerance and effectiveness of two hand decontamination procedures in everyday hospital use: Hand decontamination and skin tolerance. Br. J. Dermatol. 2000, 143, 546-550.
https://doi.org/10.1111/j.1365-2133.2000.03708.x

[5]. Greenaway, R. E.; Ormandy, K.; Fellows, C.; Hollowood, T. Impact of hand sanitizer format (gel/foam/liquid) and dose amount on its sensory properties and acceptability for improving hand hygiene compliance. J. Hosp. Infect. 2018, 100, 195-201.
https://doi.org/10.1016/j.jhin.2018.07.011

[6]. Löning, S.; Horst, C.; Hoffmann, U. Dewatering of solvent mixtures - comparison between conventional technologies and a new one. Chem. Eng. Technol. 2001, 24, 242-245.
https://doi.org/10.1002/1521-4125(200103)24:3<242::AID-CEAT242>3.0.CO;2-O

[7]. Charbonneau, D. L.; Ponte, J. M.; Kochanowski, B. A. A method of assessing the efficacy of hand sanitizers: use of real soil encountered in the food service industry. J. Food Prot. 2000, 63, 495-501.
https://doi.org/10.4315/0362-028X-63.4.495

[8]. Meadows, G. W.; Darwent, B. D. The reactions of acetaldehyde with methanol. Can. J. Chem. 1952, 30, 501-506.
https://doi.org/10.1139/v52-061

[9]. Chan, A.; Chan, T. Methanol as an unlisted ingredient in supposedly alcohol-based hand rub can pose serious health risk. Int. J. Environ. Res. Public Health 2018, 15, 1440.
https://doi.org/10.3390/ijerph15071440

[10]. Berardi, A.; Perinelli, D. R.; Merchant, H. A.; Bisharat, L.; Basheti, I. A.; Bonacucina, G.; Cespi, M.; Palmieri, G. F. Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand. Int. J. Pharm. 2020, 584, 119431.
https://doi.org/10.1016/j.ijpharm.2020.119431

[11]. Babeluk, R.; Jutz, S.; Mertlitz, S.; Matiasek, J.; Klaus, C. Hand hygiene--evaluation of three disinfectant hand sanitizers in a community setting. PLoS One 2014, 9, e111969.
https://doi.org/10.1371/journal.pone.0111969

[12]. Monteiro, C.; Proença, P.; Tavares, C.; Castañera, A.; Corte Real, F. Interference of anesthetics in blood alcohol analysis by HS-GC-FID: A case report. Forensic Sci. Int. 2016, 265, 65-69.
https://doi.org/10.1016/j.forsciint.2016.01.010

[13]. Berardi, A.; Cenci-Goga, B.; Grispoldi, L.; Cossignani, L.; Perinelli, D. R. Analysis of commercial hand sanitisers amid CoViD-19: Are we getting the products that we need? AAPS PharmSciTech 2020, 21, 286.
https://doi.org/10.1208/s12249-020-01818-6

[14]. Islam, T.; Pitafi, A. H.; Arya, V.; Wang, Y.; Akhtar, N.; Mubarik, S.; Xiaobei, L. Panic buying in the COVID-19 pandemic: A multi-country examination. J. Retail. Consum. Serv. 2021, 59, 102357.
https://doi.org/10.1016/j.jretconser.2020.102357

[15]. Mustafa, R.; Purdy, S. K.; Nelson, F. B.; Tse, T. J.; Wiens, D. J.; Shen, J.; Reaney, M. J. T. Canadian policy changes for alcohol-based hand rubs during the COVID-19 pandemic and unintended risks. World Med. Health Policy 2021. https://doi.org/10.1002/wmh3.463 (accessed May 1, 2022).
https://doi.org/10.1002/wmh3.463

[16]. Rollman, C. M.; Sanderoff, R. K.; Bezabeh, D. Z. Simultaneous quantification of ethanol and propylene glycol in nonbeverage alcohol products using gas chromatography flame ionization detection. Chromatographia 2021, 84, 97-102.
https://doi.org/10.1007/s10337-020-03981-1

[17]. Luo, F.; Darwiche, K.; Singh, S.; Torrego, A.; Steinfort, D. P.; Gasparini, S.; Liu, D.; Zhang, W.; Fernandez-Bussy, S.; Herth, F. J. F.; Shah, P. L. Performing bronchoscopy in times of the COVID-19 pandemic: Practice statement from an international expert panel. Respiration 2020, 99, 417-422.
https://doi.org/10.1159/000507898

[18]. Usp - NF (United States pharmacopeia - national formulary) 2014 main; U.S. Pharmacopeia, 2014.

[19]. World Health Organization, Novel Coronavirus (‎2019-nCoV)‎: situation report, 13. 2020. https://apps.who.int/iris/handle/10665/330778 (accessed May 1, 2022).

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The research council of Mashhad University of Medical Sciences (Code, 990773).
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