European Journal of Chemistry

Phytochemical analysis, investigation of antioxidant and anti-inflammatory activities of ethanolic and aqueous extracts of roots of Combretum glutinosum Perr. ex DC from Cote d'Ivoire

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Published: Dec 31, 2022
DOI: https://doi.org/10.5155/eurjchem.13.4.478-482.2352
Keywords:
Paw edema, Antioxidant, DPPH radical, Phytochemical, Anti-inflammatory, Combretum glutinosum
Section
Research Article
Issue
Vol. 13 No. 4 (2022): December 2022
Dates
Received 2022-09-27
Accepted 2022-10-11
Published 2022-12-31
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Sylla Tahiri
Laboratory of Environmental Sciences and Technologies, UFR Environment, Jean Lorougnon Guede University, BP 150 Daloa, Côte d'Ivoire
https://orcid.org/0000-0003-4949-7057
M’bra Kouassi Fulgence
Laboratory of Environmental Sciences and Technologies, UFR Environment, Jean Lorougnon Guede University, BP 150 Daloa, Côte d'Ivoire
https://orcid.org/0000-0002-1614-248X
Dongui Bini Kouame
Laboratory of Environmental Sciences and Technologies, UFR Environment, Jean Lorougnon Guede University, BP 150 Daloa, Côte d'Ivoire
https://orcid.org/0000-0002-8606-0877

Abstract

The phytochemical, antioxidant, and anti-inflammatory potential of root (ethanol and aqueous) extracts of Combretum glutinosum was investigated in this study. Their antioxidant activity was determined using an in vitro DPPH radical scavenging activity assay. The ethanol extract had the lowest IC50 (0.055 mg/mL), which is comparable to vitamin C. Phytochemical screening of extracts revealed the presence of sterols and polyterpenes, polyphenols, alkaloids, flavonoids, catechin tannins, gallic tannins, saponosides, terpenoids, mucilages, anthocyanins, volatile oils, and cardiac glycosides. The extracts significantly inhibit the development of paw edema induced by carrageenan. Anti-inflammatory studies showed that the inflammation inhibition potential of 200 mg/kg body weight of all extracts was significantly lower than the standard diclofenac (20 mg/kg) in the first hours. At the third hour, the inflammation inhibition potential of ethanolic and aqueous extracts was significantly higher than that of the standard. This study revealed that Combretum glutinosum extracts have anti-inflammatory effects and can act as an effective antioxidant.


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Tahiri, S.; Fulgence, M. K.; Kouame, D. B. Phytochemical Analysis, Investigation of Antioxidant and Anti-Inflammatory Activities of Ethanolic and Aqueous Extracts of Roots of Combretum Glutinosum Perr. Ex DC from Cote d’Ivoire. Eur. J. Chem. 2022, 13, 478-482.

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References

[1]. Cirak, C.; Radusiene, J.; Raudone, L.; Vilkickyte, G.; Seyis, F.; Marksa, M.; Ivanauskas, L.; Yayla, F. Phenolic compounds and antioxidant activity of Achillea arabica populations. S. Afr. J. Bot. 2022, 147, 425-433.
https://doi.org/10.1016/j.sajb.2022.02.006

[2]. Liu, Z.-Q. Why natural antioxidants are readily recognized by biological systems? 3D architecture plays a role! Food Chem. 2022, 380, 132143.
https://doi.org/10.1016/j.foodchem.2022.132143

[3]. Luna, E. M.; Lopes, H. T. O.; Rodrigues, F. A. Á.; Coutinho, H. D. M.; de Oliveira, L. C. C. Antioxidant potential of the Caatinga flora. Phytomedicine Plus 2022, 2, 100240.
https://doi.org/10.1016/j.phyplu.2022.100240

[4]. Francis, P.; Chakraborty, K. An anti-inflammatory salmachroman from the sea urchin Salmacis bicolor: a prospective duel inhibitor of cyclooxygenase-2 and 5-lipoxygenase. Nat. Prod. Res. 2021, 35, 5102-5111.
https://doi.org/10.1080/14786419.2020.1781115

[5]. Truong, V.-L.; Jeong, W.-S. Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases. Food Sci. Hum. Wellness 2022, 11, 502-511.
https://doi.org/10.1016/j.fshw.2021.12.008

[6]. Urumbil, S. K.; Anilkumar, M. N. Anti-inflammatory activity of endophytic bacterial isolates from Emilia sonchifolia (Linn.) DC. J. Ethnopharmacol. 2021, 281, 114517.
https://doi.org/10.1016/j.jep.2021.114517

[7]. Dimobe, K.; Mensah, S.; Goetze, D.; Ouédraogo, A.; Kuyah, S.; Porembski, S.; Thiombiano, A. Aboveground biomass partitioning and additive models for Combretum glutinosum and Terminalia laxiflora in West Africa. Biomass Bioenergy 2018, 115, 151-159.
https://doi.org/10.1016/j.biombioe.2018.04.022

[8]. Madièye, S.; Firmin, S. B.; Abdou, S.; Alioune, D. F.; Yacine, N.; Guata, Y. S. Y. Healing and topical anti-inflammatory activities of the total aqueous bark extract of Combretum glutinosum Perr. (Combretaceae). J. Med. Plant Res. 2020, 14, 215-224.
https://doi.org/10.5897/JMPR2019.6879

[9]. Alowanou, G. G.; Olounlade, A. P.; Azando, E. V. B.; Dedehou, V.; Daga, F. D.; Hounzangbe-adote, M. A review of Bridelia ferruginea, Combretum glutinosum and Mitragina inermis plants used in zoo therapeutic remedies in West Africa: historical origins, current uses and implications for conservation. J. Appl. Biosci. 2015, 87, 8003-8014.
https://doi.org/10.4314/jab.v87i1.4

[10]. Rana, A.; Bhakuni Negi, P.; Gopal Sahoo, N. Phytochemical screening and characterization of bioactive compounds from Juniperus squamata root extract. Mater. Today 2022, 48, 672-675.
https://doi.org/10.1016/j.matpr.2021.07.305

[11]. Alqethami, A.; Aldhebiani, A. Y. Medicinal plants used in Jeddah, Saudi Arabia: Phytochemical screening. Saudi J. Biol. Sci. 2021, 28, 805-812.
https://doi.org/10.1016/j.sjbs.2020.11.013

[12]. Lanuza, J.; Postils, V.; Lopez, X. Can aluminum, a non-redox metal, alter the thermodynamics of key biological redox processes? The DPPH-QH2 radical scavenging reaction as a test case. Free Radic. Biol. Med. 2022, 179, 200-207.
https://doi.org/10.1016/j.freeradbiomed.2021.12.308

[13]. Chen, X.; Liang, L.; Han, C. Borate suppresses the scavenging activity of gallic acid and plant polyphenol extracts on DPPH radical: A potential interference to DPPH assay. Lebenson. Wiss. Technol. 2020, 131, 109769.
https://doi.org/10.1016/j.lwt.2020.109769

[14]. Pierre Luhata, L.; Usuki, T. Free radical scavenging activities of verbascoside and isoverbascoside from the leaves of Odontonema strictum (Acanthaceae). Bioorg. Med. Chem. Lett. 2022, 59, 128528.
https://doi.org/10.1016/j.bmcl.2022.128528

[15]. Chakraborty, K.; Francis, P. Hyrtioscalaranes A and B, two new scalarane-type sesterterpenes from Hyrtios erectus with anti-inflammatory and antioxidant effects. Nat. Prod. Res. 2021, 35, 5559-5570.
https://doi.org/10.1080/14786419.2020.1795854

[16]. Chen, J.-T.; Ostermann, M. Review of anti-inflammatory and antiviral therapeutics for hospitalized patients infected with severe acute respiratory syndrome Coronavirus 2. Crit. Care Clin. 2022, 38, 587-600.
https://doi.org/10.1016/j.ccc.2022.02.002

[17]. Nikkheslat, N. Targeting inflammation in depression: Ketamine as an anti-inflammatory antidepressant in psychiatric emergency. Brain Behav Immun Health 2021, 18, 100383.
https://doi.org/10.1016/j.bbih.2021.100383

[18]. Bailly, C. Medicinal properties and anti-inflammatory components of Phytolacca (Shanglu). Digital Chinese Medicine 2021, 4, 159-169.
https://doi.org/10.1016/j.dcmed.2021.09.001

[19]. Adem, S. R.; Ayangbenro, A. S.; Gopane, R. E. Phytochemical screening and antimicrobial activity of Olea europaea subsp. africana against pathogenic microorganisms. Scientific African 2020, 10, e00548.
https://doi.org/10.1016/j.sciaf.2020.e00548

[20]. Ahmed, H. M. Phytochemical screening, total phenolic content and phytotoxic activity of corn (Zea mays) extracts against some indicator species. Nat. Prod. Res. 2018, 32, 714-718.
https://doi.org/10.1080/14786419.2017.1333992

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