European Journal of Chemistry

Synthesis and antitumor activity of novel pyrazolo[1,5-a]pyrimidine derivatives



Main Article Content

Mervat Mostafa El-Enany
Mona Monir Kamel
Omneya Mahmoud Khalil
Hala Bakr El-Nassan

Abstract

A novel series of pyrazolo[1,5-a]pyrimidine-3-carbonitriles substituted with 7-amino, 7-substituted amino and 5-substituted amino groups was synthesized. Some of the newly synthesized compounds were tested in vitro on human colon tumor cell line (HCT116). Compound 14a displayed the highest activity among the tested compounds with IC50 that equals to 0.0020 μM.

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El-Enany, M. M.; Kamel, M. M.; Khalil, O. M.; El-Nassan, H. B. Synthesis and Antitumor Activity of Novel pyrazolo[1,5-a]pyrimidine Derivatives. Eur. J. Chem. 2011, 2, 331-336.

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