European Journal of Chemistry

Synthesis, characterization and crystal structure of 1-(4-methylbenzoyl)-3-(4 aminosulfonylphenyl)thiourea



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Aamer Saeed
Amara Mumtaz
Ulrich Florke

Abstract

An efficient synthesis of the title compound, 1-(4-methylbenzoyl)-3-(4-aminosulfonyl phenyl)thiourea,  was carried out by reaction of 4-methylbenzoyl chloride with potassium thiocyanate in acetone to afford 4-methylbenzoyl isothiocyanate in situ followed by treatment with sulfanilamide. The structure was confirmed by spectroscopic data and elemental analyses. The molecular structure was determined from single crystal X-ray diffraction data. It crystallizes in the monoclinic space group P21/n with unit cell dimensions of a = 4.8116(9) Å, b = 17.150(3) Å, c = 18.677(3) Å, γ = 96.487(4) °, and V = 1531.4(5) Å3.

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Saeed, A.; Mumtaz, A.; Florke, U. Synthesis, Characterization and Crystal Structure of 1-(4-Methylbenzoyl)-3-(4 aminosulfonylphenyl)thiourea. Eur. J. Chem. 2010, 1, 73-75.

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