European Journal of Chemistry

Regioselective synthesis of new 2-(E)-cyano(oxazolidin-2-ylidene)thiazoles

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Mehdi Bakavoli
Hamid Beyzaei
Mohammad Rahimizadeh
Hossein Eshghi


Reaction of 2-(oxazolidin-2-ylidene)malononitrile (1) with phosphorus pentasulfide gave the corresponding thioamide derivative (2a) in a regioselective manner. Reaction of this compound with several α-bromocarbonyl compounds gave new 2-(E)-cyano(oxazolidin-2-ylidene)thiazoles (3a-g). The chemical structures of novel compounds were confirmed by 1H NMR, elemental analysis, FT-IR spectrometry and mass spectrophotometric analyses.


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Bakavoli, M.; Beyzaei, H.; Rahimizadeh, M.; Eshghi, H. Regioselective Synthesis of New 2-(E)-cyano(oxazolidin-2-ylidene)thiazoles. Eur. J. Chem. 2011, 2, 356-358.

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