European Journal of Chemistry

Facile synthesis of 3-(1-(4'-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)biphenyl-4-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones: β-Lactam derivatives as antimicrobes

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Abha Bishnoi
Krishna Srivastava
Suruchi Singh
Chandrakant Mani Tripathi


A facile synthesis of b-lactam derivatives; 3-(1-(4'-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)biphenyl-4-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones (6a-e) and 3-(1-(3-chloro-2-(substituted phenyl)-4-oxoazetidin-1-yl)-5-oxo-2-phenyl-1H-imidazol-4(5H)-ylidene)indolin-2-ones (7a-e) is described herein. The title compounds 6a-e and 7a-e were evaluated for their in vitro antimicrobial activity against Candida albicans and Bacillus subtilis respectively using a two fold serial dilution technique. Investigation revealed that 2-hydroxy phenyl function at b-lactam ring in compounds 6d and 7d is a key factor for both antifungal and antibacterial activity, as newly designed compounds 6d and 7d exhibited good biological activity with minimum inhibitory concentration (MIC)12.5 mg/mL against Candida albicans and Bacillus subtilis respectively.


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Bishnoi, A.; Srivastava, K.; Singh, S.; Tripathi, C. M. Facile Synthesis of 3-(1-(4’-(3-Chloro-2-(substituted Phenyl)-4-Oxoazetidin-1-yl)biphenyl-4-Yl)-5-Oxo-2-Phenyl-1H-Imidazol-4(5H)-ylidene)indolin-2-Ones: β-Lactam Derivatives As Antimicrobes. Eur. J. Chem. 2011, 2, 359-364.

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[1]. Rang, H. P.; Dale, M. M.; Ritter, J. M.; Flower, R. J. Rang and Daleâs Pharmacology, Churchill Livingstone, International Edition, USA, 2003.

[2]. Yu, L. T.; Ho, M. T.; Chang, C. Y.; Yang, T. K. Tetrahedron: Asym. 2007, 18(8), 949-962.

[3]. Gupta, A.; Unadkat, J. D.; Mao, Q. J. Pharma. Sci. 2007, 96(12), 3226-3235.

[4]. Schiller, S. D.; Fung, H. B. Clin. Ther. 2007, 29(9), 1862-1886.

[5]. Ashok, M.; Holla, B. S.; Poojary, B. Eur. J. Med. Chem. 2007, 42(8), 1095-1101.

[6]. Van Cutsem, J. M.; Thienpont, D. Chemotherapy 1972, 17(6), 392-404.

[7]. Kokjohn, K.; Bradly, M.; Griffiiths, B.; Ghannoum, M. Int. J. Dermatol. 2003, 42(S1), 11-17.

[8]. McLean, K. J.; Marshall, K. R.; Richmond, A.; Hunter, I. S.; Fowler, K.; Kieser, T. Microbiology 2002, 148, 2937-2949.

[9]. Ucucu, U.; Karaburun, N. G.; Isikdag, I. Farmaco. 2001, 56(4), 285-290.

[10]. Yesilada, A.; Koyunoglu, S.; Saygilia, N.; Kupeli, E.; Yesilada, E.; Bedir, E. Khanc, I. Arch. Pharm. Pharm. Med. Chem. 2004, 337, 96-104.

[11]. Quattara, L.; Debaert, M.; Cavier, R. Farmaco. (Sci) 1987, 42(6), 449-456.

[12]. Dutta, S.; Mariappan, G.; Roy, S.; Verma, M. Indian Drugs 2009, 46(7), 50-53.

[13]. Sengupta, A. K.; Bhattacharya, T. J. Indian Chem. Soc. 1983, 60, 373-376.

[14]. Navidpour, L.; Shadnia, H.; Shafaroodi, H.; Amini, M.; Dehpour, A. R.; Shafiee, A. Bioorg. Med. Chem. 2007, 15(5), 1976-1982.

[15]. Driscoll, M. O.; Greenhalgh, K.; Young, A.; Turos, E.; Dickey, S.; Lim, D. V. Bioorg. Med Chem. 2008, 16(16), 7832-7837.

[16]. Banik, B. K.; Becker, F. F.; Banik, I. Bioorg. Med Chem. 2004, 12(10), 2523-2528.

[17]. Banik, B. K.; Banik, I.; Becker, F. F. Bioorg. Med Chem. 2005, 13(11), 3611-3622.

[18]. Banik, B. K.; Banik, I.; Becker, F. F. Eur. J. Med Chem. 2010, 45(2), 846-848.

[19]. Zhang, W.; Richardson, R. D.; Chamni, S.; Smith, J. W.; Romo, D. Bioorg. Med Chem. Lett. 2008, 18(7), 2491-2494.

[20]. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests. Approved standard. NCCLS document M2-A5. Wayne, Pa: National Committee for Clinical Laboratory Standards; 1997.

[21]. Sahm, D. F.; Washington, J. A. Manual of Clinical Microbiology, 5th Ed., ASM, Washington DC, 1991.

[22]. Lopez, R.; Sordo, T. L.; Sordo, J. A.; Gonzalez, J. J. Org. Chem. 1993, 58, 7036-7037.

[23]. VanBrabandt, W.; Vanwalleghem, M.; Dâhooghe, M.; De Kimpe, N. J. Org. Chem. 2006, 71, 7083-7086.

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University Grants Commission, Central Drug Research Institute, India
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