European Journal of Chemistry

Conductometric titration method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl using silver nitrate

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Published: Sep 30, 2012
DOI: https://doi.org/10.5155/eurjchem.3.3.332-336.637
Keywords:
Oxalate, Sotalol HCl, Silver nitrate, Propafenone HCl, Naftidrofuryl oxalate, Conductometric titration
Section
Research Article
Issue
Vol. 3 No. 3 (2012): September 2012
Dates
Received 2012-05-15
Accepted 2012-07-10
Published 2012-09-30


Main Article Content

Magda Mohamed Ayad
Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
Hisham Ezzat Abdellatef
Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
Mervat Mohamed Hosny
Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt
Yassmin Ahmed Sharaf
Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, 44519, Egypt

Abstract

A simple, precise, rapid, and low-cost conductometric method for determination of naftidrofuryl oxalate, propafenone HCl and sotalol HCl in pure form and in pharmaceutical formulations using silver nitrate has been described. The method is based on the precipitation of oxalate or chloride ions coming from the cited drugs with silver ions, yielding silver oxalate or silver chloride and the conductance of the solution is measured as a function of the volume of titrant. The studied drugs were evaluated in double distilled water in the range of 1-15 mg. Various experimental conditions were established and results obtained showed good recoveries with relative standard deviation of 0.909, 0.955 and 0.983 for naftidrofuryl, propafenone and sotalol, respectively. The proposed procedures were applied successfully to the analysis of these drugs in their pharmaceutical formulations. Results were favorably comparable to the official or reference methods.

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Ayad, M. M.; Abdellatef, H. E.; Hosny, M. M.; Sharaf, Y. A. Conductometric Titration Method for Determination of Naftidrofuryl Oxalate, Propafenone HCl and Sotalol HCl Using Silver Nitrate. Eur. J. Chem. 2012, 3, 332-336.

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References

[1]. The British Pharmacopoeia, Volumes II and III, Her Majesty’s Stationery Office, London, UK, 2008.

[2]. Sweetman, S. C. Martindale-The Complete Drug Reference, 35th edition, The Pharmaceutical Press, London, 2007.

[3]. Belal, T. S.; Barary, M. H.; Sabry, S. M.; Ibrahim, M. A. J. Food Drug Anal. 2009, 17, 415-423.

[4]. Sabry, S. M.; Belal, T. S.; Barary, M. H.; Ibrahim, M. A. Int. J. Biomed. Sci. 2009, 5, 283-292.

[5]. Walmsley, L. M.; Wilkinson, P. A.; Brodie, R. R.; Chasseaud, L. F. J. Chromatogr. 1985, 338, 433-437.
http://dx.doi.org/10.1016/0378-4347(85)80117-1

[6]. Waaler, P. J.; Mueller, B. W. Int. J. Pharm. 1992, 87, 223-227.
http://dx.doi.org/10.1016/0378-5173(92)90246-X

[7]. Brodie, R. R.; Chasseaud, L. F.; Taylor, T. J. Chromatogr. 1979, 164, 534-540.
http://dx.doi.org/10.1016/S0378-4347(00)81559-5

[8]. Garrett, E. R.; Barbhaiya, R.; J. Pharm. Sci. 1981, 70, 39-45.
http://dx.doi.org/10.1002/jps.2600700106
PMid:7229928

[9]. Munoz, A.; Espinosa, A.; Murillo, J. A. Analyst 1998, 123, 2285-2290.
http://dx.doi.org/10.1039/a804632h

[10]. Murillo, A.; Alanon, A.; Fernandez, P. Anal. Chim. Acta 1999, 382, 77-85.
http://dx.doi.org/10.1016/S0003-2670(98)00793-4

[11]. Segura, A.; Cruces, C.; Canabate, B. Anal.C him. Acta 2000, 417, 19-30.
http://dx.doi.org/10.1016/S0003-2670(00)00917-X

[12]. Cruces, C.; Segura, A.; Fernandez, J. F.; Fernandez, A. J. Pharm. Biomed. Anal. 2000, 23, 845-850.
http://dx.doi.org/10.1016/S0731-7085(00)00391-5

[13]. Ionescu, M. S.; Badea, V.; Baiulescu, G. E.; Cosofret, V. V. Talanta 1986, 33, 101-103.
http://dx.doi.org/10.1016/0039-9140(86)80021-2

[14]. Fernandez-Sanchez, J. F.; Segura-Carretero, A.; Cruces-Blanco, C.; Fernandez-Gutierrez, A. Anal. Chim. Acta 2002, 462, 217-224.
http://dx.doi.org/10.1016/S0003-2670(02)00348-3

[15]. United States Pharmacopoeia, XXIV, United States Pharmacopoeia Convention, Washington, DC, 2007.

[16]. Dhandapani, B.; Keerthi, J.; Babunaik, M.; Lavanya, L.; Priyamvadha, D. L.; Manjeera, K. K; Anusha, B. H.; Celestin Baboo, R. V. Int. J. Pharm. Biomed. Res. 2010, 1, 49-53.

[17]. El-Dawy, M. A.; Mabrouk, M. M.; EL Barbary R. A. Chem. Pharm. Bull. 2006, 54, 1026-1029.

[18]. Li, G. B.; Lin, X. L.; Zhu, C. F.; Hao, A. Y.; Guan, Y. F. Anal. Chim. Acta 2000, 421, 27-34.
http://dx.doi.org/10.1016/S0003-2670(00)00960-0

[19]. Chankvetadze, B.; Lomsadze, K.; Blaschke, G. J. Sep. Sci. 2001, 24, 795-801.
http://dx.doi.org/10.1002/1615-9314(20010901)24:9<795::AID-JSSC795>3.0.CO;2-V

[20]. Brode, E.; Kripp, U.; Hollmann, M. Arznei. Forschung 1984, 34, 1455-1460.
PMid:6151841

[21]. Brode, E.; Kripp, U.; Breckwoldt, W. Methods 1988, 10, 319-329.

[22]. Afshar, M.; Rouini, M. Anal. Sci. 2004, 20, 1307-1311.
http://dx.doi.org/10.2116/analsci.20.1307
PMid:15478341

[23]. Lamprecht, G.; Stoschitzky, K. J. Chromatogr. B 2009, 877, 3489-3494.
http://dx.doi.org/10.1016/j.jchromb.2009.08.024
PMid:19736049

[24]. Buszewski, B.; Nowaczyk, J.; Ligor, T.; Olszowy, P.; Ligor, M.; Wasiniak, B.; Miekisch, W.; Schubert, J. K.; Amann, A. J. Sep. Sci. 2009, 32, 2448-2454.
http://dx.doi.org/10.1002/jssc.200900094
PMid:19569094

[25]. Sultan, S. M.; Bukhari, A. M.; Perzanowski, H. J. Pharmaceut. Biomed. 1990, 8, 569-571.
http://dx.doi.org/10.1016/0731-7085(90)80081-Y

[26]. Banerjee, S. K.; Mashru, R. Indian J. Pharm. Sci. 1991, 53, 243-244.

[27]. Wang, W.; Zhao, G.; Cheng, X.; Jiang, W. J. Shandong Medical University 2001, 39, 215-217.

[28]. Amin, A. S.; Ragab, G. H.; Saleh, H. J. Pharmaceut. Biomed. 2002, 30, 1347-1353.
http://dx.doi.org/10.1016/S0731-7085(02)00205-4

[29]. Santoro, M. I. R. M.; Tsubone, C.; Gomes, F. P.; Kedor-Hackmann, E. R. M.; Garcia, P. G. Anal. Lett. 2008, 41, 2044-2057.
http://dx.doi.org/10.1080/00032710802209342

[30]. Garrett, E. R.; Schnelle, K. J. Pharm. Sci. 1971, 60, 833-839.
http://dx.doi.org/10.1002/jps.2600600607
PMid:4399660

[31]. Zhang, H.; Yang, J.; Du, L.; Li, C.; Wu, H. Anal. Methods 2011, 3, 1156-1162.
http://dx.doi.org/10.1039/c0ay00728e

[32]. Stephanie, S.; Wauer, I.; Scholz, H. J. Chromatogr. B 2001, 753, 421-425.
http://dx.doi.org/10.1016/S0378-4347(00)00562-4

[33]. Rbeida, O.; Christiaens, B.; Chiap, P.; Hubert, P.; Lubda, D.; Boos, K.; Crommen, J. Pharmaceut. Biomed. 2003, 32, 829-838.
http://dx.doi.org/10.1016/S0731-7085(03)00186-9

[34]. Dogrukol-Ak, D.; Dal, A., G.; Tuncel, M. Chromatographia 2007, 66, 159-163.
http://dx.doi.org/10.1365/s10337-007-0312-9

[35]. Iorio, M. A.; Mazzeo-Farina, A.; Doldo, A. J. Pharmaceut. Biomed. 1987, 5, 1-10.
http://dx.doi.org/10.1016/0731-7085(87)80002-X

[36]. Belal, F.; Rizk, F. A.; El-Enany, N. M, Chem. Anal. 1999, 44, 763-772.

[37]. Sartori, E. R.; Suarez, W. T.; Fatibello-Filho, O. Quim. Nova 2009, 32, 1947-1950.
http://dx.doi.org/10.1590/S0100-40422009000700043

[38]. Fabio, R. C.; Ava, G.; Marcio, F. B.; Luiz, H. M. Curr. Pharm. Anal. 2011, 7, 275-279.

[39]. Lingane, J. J. Electroanalytical Chemistry, 2nd Ed., Interscience, New York, 90, 1958.

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