European Journal of Chemistry

On the effect of chelating agents and antioxidants on cadmium-induced organ toxicity. An overview

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Published: Mar 31, 2013
DOI: https://doi.org/10.5155/eurjchem.4.1.74-84.739
Keywords:
Vitamins, Cadmium, Toxicology, Ionophores, Antioxidants, Medicinal chemistry
Section
Review Article
Issue
Vol. 4 No. 1 (2013): March 2013
Dates
Received 2013-01-31
Accepted 2013-02-16
Published 2013-03-31


Main Article Content

Juliana Ivanova
Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
Yordanka Gluhcheva
Institute of Experimental Morphology, Pathology and Anthropology with Museum, BAS, 1113, Sofia, Bulgaria
Denitsa Tsanova
Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
Angelina Piskova
Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
Radostina Djaleva
Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
Steliana Mokresheva
Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
Dimitrina Kamenova
Faculty of Medicine, Sofia University “St. Kl. Ohridski”, 1407 Sofia, Bulgaria
Mariana Mitewa
Faculty of Chemistry and Pharmacy, Sofia University, “St. Kl. Ohridski”, 1164 Sofia, Bulgaria

Abstract

Cadmium (Cd) has been classified as a human carcinogen. The World Health Organization (WHO) reported that the concentration of Cd in the environment has rapidly increased in the last few years. In many epidemiological studies, the correlation between environmental exposure of humans to Cd and diseases such as stroke, ischemia, renal and hepatic dysfunction, anemia, osteoporosis and diabetes has been discussed. For the treatment of heavy metal intoxications a therapy with chelating agents has been applied. A chelating agent is a compound that binds the toxic metal ion thus promoting its excretion by the living organisms. Recently, it has been found that Cd-induced toxicity is a result of formation of reactive oxygen species (ROS). These results increased the interest towards the antioxidants as possible agents for the treatment of Cd-induced organ toxicity. Herein, we present summary and discussion of the literature data for the influence of chelating agents and antioxidants on Cd-induced pathological conditions in Cd-intoxicated animals.

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Ivanova, J.; Gluhcheva, Y.; Tsanova, D.; Piskova, A.; Djaleva, R.; Mokresheva, S.; Kamenova, D.; Mitewa, M. On the Effect of Chelating Agents and Antioxidants on Cadmium-Induced Organ Toxicity. An Overview. Eur. J. Chem. 2013, 4, 74-84.

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