European Journal of Chemistry 2014, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120

Synthesis and biological evaluation of new quinazolinone derivatives

Firyal Weli Asker (1) , Salma Abdul Rudha Abbas (2,*) , Redha Ibrahim Al-Bayati (3) , Hanaa Abd Al-Tamemi (4)

(1) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(2) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(3) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(4) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(*) Corresponding Author

Received: 12 Jul 2014, Accepted: 15 Aug 2014, Published: 31 Dec 2014


New N-substituted-2-methyl quinazolin-4(3H)-ones derivatives comprising 1,3,4-thiadiazole, Schiff bases and 2-azetidinone moieties are reported. The structures of the newly prepared compounds were confirmed by FT-IR and 1H NMR spectra. The compounds were also evaluated for their antimicrobial, antioxidant and study of inhibition on some enzymes activities. The results suggest that the compounds possess broad spectrum of in-vitro antimicrobial activity. Antioxidant results obtained into the present study indicate that compound 5 show moderate better scavenging activity. Compound 5 demonstrated inhibitory effects on GOT, GPT, GGT and ALP activities, and these effects increase with increasing the concentration of the compound.


Schiff bases; Azetidinone; Quinazolinone; Enzymes activities; Antioxidant activity; Antimicrobial activity

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DOI: 10.5155/eurjchem.5.4.628-634.1120

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How to cite

Asker, F.; Abbas, S.; Al-Bayati, R.; Al-Tamemi, H. Eur. J. Chem. 2014, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120
Asker, F.; Abbas, S.; Al-Bayati, R.; Al-Tamemi, H. Synthesis and biological evaluation of new quinazolinone derivatives. Eur. J. Chem. 2014, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120
Asker, F., Abbas, S., Al-Bayati, R., & Al-Tamemi, H. (2014). Synthesis and biological evaluation of new quinazolinone derivatives. European Journal of Chemistry, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120
Asker, Firyal, Salma Abdul Rudha Abbas, Redha Ibrahim Al-Bayati, & Hanaa Abd Al-Tamemi. "Synthesis and biological evaluation of new quinazolinone derivatives." European Journal of Chemistry [Online], 5.4 (2014): 628-634. Web. 22 Nov. 2019
Asker, Firyal, Abbas, Salma, Al-Bayati, Redha, AND Al-Tamemi, Hanaa. "Synthesis and biological evaluation of new quinazolinone derivatives" European Journal of Chemistry [Online], Volume 5 Number 4 (31 December 2014)

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