Oxetanes as versatile building blocks in the total synthesis of natural products: An overview

Ahmed Mahal

doi:10.5155/eurjchem.6.3.357-366.1267

PDF

Published: Sep 30, 2015

DOI: https://doi.org/10.5155/eurjchem.6.3.357-366.1267

Keywords:

Oxetane, Anti-tumor, Drug discovery, Small molecules, Natural products, Heterocyclic synthesis

Section

Review Article

Issue

Vol. 6 No. 3 (2015): September 2015

Dates

Received 2015-04-27
Accepted 2015-06-01
Published 2015-09-30

Ahmed Mahal

Department of Chemistry of the Natural Products, School of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Napoli, Italy

Abstract

Oxetane ring plays an important role as main core in naturally occurring compounds and has many applications in pharmaceutical industries and synthetic organic chemistry. In this review, we report a brief survey of using the oxetane ring as versatile precursors in the total synthesis of natural products. Many approaches such as cyclization, addition, oxidation, reduction, elimination, protection as well as deprotection reactions utilized to synthesize of most important oxetane-containing natural products involving taxol, (±)-merrilactone A, (±)-oxetin, L-oxetanocin, (+)-(Z)-laureatin and L-oxetanocin are also covered. We describe in this review the most common total synthesis approaches have been yet applied to synthesis of most important oxetane-containing natural products. The review is also included isolation, structure Identification of these oxetane-containing natural products. The biological activity of oxetane-containing natural products due to the oxetane ring is also defined.

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Mahal, A. Oxetanes As Versatile Building Blocks in the Total Synthesis of Natural Products: An Overview. Eur. J. Chem. 2015, 6, 357-366.

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Supporting Agencies

University of Naples Federico II, Napoli, Italy

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