European Journal of Chemistry 2016, 7(1), 56-65 | doi: https://doi.org/10.5155/eurjchem.7.1.56-65.1372 | Get rights and content






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Synthesis, characterization, mass spectral fragmentation, thermal study and biological evaluation of new Schiff base ligand and its metal(II) complexes derived from 4-(diethylamino)salicylaldehyde and thiazole moiety


Nagesh Gunvanthrao Yernale (1) , Mahadev Dhanraj Udayagiri (2) , Bennikallu Hire Mathada Mruthyunjayaswam (3,*)

(1) Department of Studies and Research in Chemistry, Gulbarga University, Kalaburagi, 585106, Karnataka, India
(2) Government Degree College, Sedam Road, Kalaburagi, 585106, Karnataka, India
(3) Department of Studies and Research in Chemistry, Gulbarga University, Kalaburagi, 585106, Karnataka, India
(*) Corresponding Author

Received: 24 Nov 2015 | Revised: 18 Dec 2015 | Accepted: 19 Dec 2015 | Published: 31 Mar 2016 | Issue Date: March 2016

Abstract


A new Schiff base ligand, 2-(4-(diethylamino)-2-hydroxybenzylidene)-N-(4-phenylthiazol-2-yl) hydrazinecarboxamide (L) and its copper(II), cobalt(II), nickel(II) and zinc(II) complexes were prepared and characterized by analytical and spectroscopic methods. The analytical data suggests the composition of the metal complexes to be 1:2 of the type [ML2] for copper(II), cobalt(II) and nickel(II) complexes and 1:1 stoichiometry of the type [MLCl] for zinc(II) complex, where L is the deprotonated Schiff base ligand. The conductance measurement data indicates that all the metal complexes are non-electrolytes. The antioxidant activity of all the compounds was evaluated using the DPPH assay. The Schiff base ligand (L) and its copper(II), cobalt(II) complexes are found to be good antioxidants. The antibacterial and antifungal activity was performed by agar diffusion methods. All the metal(II) complexes inhibited the growth of bacteria and fungi. Also, brine shrimp bioassay was also carried out to study the in vitro cytotoxic properties, the copper(II) and zinc(II) complexes showed good cytotoxic property.


Keywords


Thiazole; Schiff base; Mass fragmentation; Antibacterial activity; Transition metal complexes; 4-(Diethylamino)salicylaldehyde

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DOI: 10.5155/eurjchem.7.1.56-65.1372

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Funding information


Department of Science and Technology, New Delhi for the award of DST-INSPIRE SRF [DST/AORC-IF/UPGRD/ 2014-15/IF120091].

Citations

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[1]. Ranjan K. Mohapatra, Pradeep K. Das, Manoj K. Pradhan, Abdussalam A. Maihub, Marei M. El-ajaily
Biological aspects of Schiff base–metal complexes derived from benzaldehydes: an overview
Journal of the Iranian Chemical Society  15(10), 2193, 2018
DOI: 10.1007/s13738-018-1411-2
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[2]. Tasneem Ibrahim Hussein, Musa Abduelrahman Ahmed, Ismail Adam Arbab, Awad Salim Ibrahim, Mohamed Al-Bratty, Hassan Ahmed Alhazmi, Asim Najmi
Synthesis, characterization and biological activity of a Schiff base derived from o-amino benzoic acid and its Co(II), Cd(II) and Ni(II) complexes
European Journal of Chemistry  11(1), 15, 2020
DOI: 10.5155/eurjchem.11.1.15-20.1941
/


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How to cite


Yernale, N.; Udayagiri, M.; Mruthyunjayaswam, B. Eur. J. Chem. 2016, 7(1), 56-65. doi:10.5155/eurjchem.7.1.56-65.1372
Yernale, N.; Udayagiri, M.; Mruthyunjayaswam, B. Synthesis, characterization, mass spectral fragmentation, thermal study and biological evaluation of new Schiff base ligand and its metal(II) complexes derived from 4-(diethylamino)salicylaldehyde and thiazole moiety. Eur. J. Chem. 2016, 7(1), 56-65. doi:10.5155/eurjchem.7.1.56-65.1372
Yernale, N., Udayagiri, M., & Mruthyunjayaswam, B. (2016). Synthesis, characterization, mass spectral fragmentation, thermal study and biological evaluation of new Schiff base ligand and its metal(II) complexes derived from 4-(diethylamino)salicylaldehyde and thiazole moiety. European Journal of Chemistry, 7(1), 56-65. doi:10.5155/eurjchem.7.1.56-65.1372
Yernale, Nagesh, Mahadev Dhanraj Udayagiri, & Bennikallu Hire Mathada Mruthyunjayaswam. "Synthesis, characterization, mass spectral fragmentation, thermal study and biological evaluation of new Schiff base ligand and its metal(II) complexes derived from 4-(diethylamino)salicylaldehyde and thiazole moiety." European Journal of Chemistry [Online], 7.1 (2016): 56-65. Web. 2 Jun. 2020
Yernale, Nagesh, Udayagiri, Mahadev, AND Mruthyunjayaswam, Bennikallu. "Synthesis, characterization, mass spectral fragmentation, thermal study and biological evaluation of new Schiff base ligand and its metal(II) complexes derived from 4-(diethylamino)salicylaldehyde and thiazole moiety" European Journal of Chemistry [Online], Volume 7 Number 1 (31 March 2016)

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