European Journal of Chemistry 2016, 7(2), 152-155 | doi: https://doi.org/10.5155/eurjchem.7.2.152-155.1403 | Get rights and content






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Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction


Mohammed Abed Al-Hussein Salman (1) , Nabeel Abed Abdul-Rida (2,*)

(1) Department of Chemistry, College of Education, Al-Qadisiyah University, 58002, Diwaniya, Iraq
(2) Department of Chemistry, College of Education, Al-Qadisiyah University, 58002, Diwaniya, Iraq
(*) Corresponding Author

Received: 01 Feb 2016 | Accepted: 27 Feb 2016 | Published: 30 Jun 2016 | Issue Date: June 2016

Abstract


A new series of aryl clonazepam derivatives (11-16) have been synthesized by employing Suzuki Cross-coupling reaction, which includes the reaction of clonazepam with suitable derivative boronic acid at the presence of Pd(PPh3)4 as catalyst, and Na2CO3 as a base. The structures of the newly synthesized compounds were assigned by 1H, 13C and 2D NMR spectroscopic techniques.


Keywords


Clonazepam; Diazepine ring; GABA receptor; 2D NMR spectroscopy; Benzodiazepine derivatives; Suzuki Cross-coupling reaction

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DOI: 10.5155/eurjchem.7.2.152-155.1403

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Funding information


Al-Qadisiyah University, 58002, Diwaniya, Iraq

Citations

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[1]. Kamal J. Awni, Mohammed A. Aboktifa, Mohammed A. Salman, Adnan M. Jasim
CHARACTERIZATION AND SYNTHESIS OF NEW MODEL OF DERIVATIVE COLONAZEPAM AND CLINICAL TRIAL TO INSPECTION OF ADVERSE EFFECT IN MALE MICE
IOP Conference Series: Earth and Environmental Science  553, 012020, 2020
DOI: 10.1088/1755-1315/553/1/012020
/


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How to cite


Salman, M.; Abdul-Rida, N. Eur. J. Chem. 2016, 7(2), 152-155. doi:10.5155/eurjchem.7.2.152-155.1403
Salman, M.; Abdul-Rida, N. Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction. Eur. J. Chem. 2016, 7(2), 152-155. doi:10.5155/eurjchem.7.2.152-155.1403
Salman, M., & Abdul-Rida, N. (2016). Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction. European Journal of Chemistry, 7(2), 152-155. doi:10.5155/eurjchem.7.2.152-155.1403
Salman, Mohammed, & Nabeel Abed Abdul-Rida. "Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction." European Journal of Chemistry [Online], 7.2 (2016): 152-155. Web. 31 Oct. 2020
Salman, Mohammed, AND Abdul-Rida, Nabeel. "Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction" European Journal of Chemistry [Online], Volume 7 Number 2 (30 June 2016)

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DOI Link: https://doi.org/10.5155/eurjchem.7.2.152-155.1403

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