OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS
Spectrofluorimetric analysis of menbutone in veterinary formulations: Application to residue determination in bovine meat and milk
Fathalla Belal (1) , Sawsan Abdel-Moneim Abd El-Razeq (2) , Manal Mohamed Fouad (3) , Fatma Ahmed Fouad (4,*)
(1) Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, University of Mansoura, Mansoura, 35516, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, 11754, Egypt
(3) Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, 11754, Egypt
(4) Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, 11754, Egypt
(*) Corresponding Author
Received: 04 Feb 2016 | Revised: 04 Mar 2016 | Accepted: 05 Mar 2016 | Published: 30 Jun 2016 | Issue Date: June 2016
A simple, rapid, and sensitive spectroflourimetric method was developed for the determination of menbutone. The method is based on measuring the native fluorescence of the alkaline aqueous methanolic solution of the cited drug at its optimum excitation and emission wavelengths at λem 378 nm, upon excitation at λex 300 nm. The method showed good linearity over the range of 0.2-2.0 µg/mL with a detection and quantitation limits of 7.25 and 24.15 ng/mL, respectively. The suggested method was successfully applied to the analysis of menbutone in its commercial veterinary formulations and the results obtained were in good agreement with those given with the manufacturer method. The method was further extended to the determination of menbutone residues in bovine meat and milk, and the results were satisfactory. The recoveries obtained were in the 98.50-102.25% range. No organic solvents were used in the extraction procedures, therefore, the proposed method can be considered as a type of 'green' chemical process.
Links for Article
| | | | | | |
| | | | | | |
Article MetricsThis Abstract was viewed 807 times | PDF Article downloaded 260 times
The Unit of Drug Analysis at the Faculty of Pharmacy, Mansoura University, Mansoura,
. O' Neil, J. M. The Merck Index, 14th Ed., Merck and Co., Inc., Rahway, UDA, 2006.
. Symonds, H.W. Vet. Rec. 1982, 110, 423-425.
. Ackerman, L. Veterinary Practice Management, Black Well Publications, New Jersey, 2007.
. Rodriguez, E.; Moreno-Bondi, M.C.; Marazuela, M.D. J. Chromatogr. A 2008, 1209, 136-144.
. Lund, J.; Lassen, J. B. Acta Pharmacol. Toxicol. 1969, 27, 429-438.
. Fouad, M. M.; Abdel-Razeq, S. A.; Belal, F. F.; Fouad, F. A. Int. J. Pharm. Anal. 2013, 4, 30-35.
. Luo, Y.; Tan, M.; Luo, L.; Wang, L.; Yang, Y.; Long, F.; Wang, S.; Wu, M. Faming Zhuanli Shenqing 2013, 12, 11-16.
. Luo, Y.; Tan, M.; Luo, L.; Wang, L.; Yang, Y.; Long, F.; Wang, S.; Wu, M. Faming Zhuanli Shenqing 2013, 12, 4-10.
. Belal, F.; Abdel-Razeq, S. A.; Fouad, M. M.; Zayed, S.; Fouad, F. A. Food Anal. Method 2016, 9, 638-645.
. Shoichiro, N.; Hisaya, T. Nagoya-Shi Eisei Kenkyushoho 2008, 54, 1-5.
. Hirosh, M.; Kouhei, F.; Toshiaki, T. Kumamoto-Ken Hoken Kankyo Kagaku Kenkyushoho 2010, 39, 21-25.
. Nasr, J. J.; Shalan, S. Luminescence 2014, 29(8), 1188-1193.
. Belal, F.; Sharaf El-Din, M. K.; Tolba, M. M.; Elmansi, H. J. Fluorescence 2014, 24(1), 85-91.
. Ayad, M. M.; Abdellatef, H. E.; Hosny, M. M.; Sharaf, Y. A. Eur. J. Chem. 2013, 4(1), 35-43.
. Munson, J. W. Pharmaceutical analysis, Part A, Marcel Dekker, Inc., New York, USA, 1981.
. International Conference on Harmonization (ICH). Technical Requirements for the Registration of Pharmaceutical for Human Use, Validation of Analytical Procedures; Text and methodology Q2 (R1), Geneva, 2005.
. Miller, J. N.; Miller, J. C. Statistics and chemometrics for analytical chemistry, 5th Ed., Pearson Education Limited, Harlow, England, 2005.
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.7.2.156-160.1405
| | | | | | |
| | | | | |
Save to Zotero Save to Mendeley
European Journal of Chemistry 2016, 7(2), 156-160 | doi: https://doi.org/10.5155/eurjchem.7.2.156-160.1405 | Get rights and content
- There are currently no refbacks.
© Copyright 2010 - 2020 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2020 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.