European Journal of Chemistry 2016, 7(2), 248-270 | doi: https://doi.org/10.5155/eurjchem.7.2.248-270.1412 | Get rights and content






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Recent advance in direct sp3 carbon-hydrogen bond functionalizations


Xiao-Hua Cai (1,*) , Jun Jin (2) , Bing Xie (3)

(1) National School of Medicine, Guizhou Minzhu University, Guiyang 550025, China
(2) National School of Medicine, Guizhou Minzhu University, Guiyang 550025, China
(3) National School of Medicine, Guizhou Minzhu University, Guiyang 550025, China
(*) Corresponding Author

Received: 20 Feb 2016 | Accepted: 19 Mar 2016 | Published: 30 Jun 2016 | Issue Date: June 2016

Abstract


Direct and selective carbon-hydrogen bond functionalization has attracted enormous attention because it provides more efficient strategies for preparing valuable functional molecules from easily available substrates. Significant and exciting developments in functionalization of un-activation Csp3-H bonds have continuously been made over the past few decades. This review mainly summarizes recent advances on direct Csp3-H bond functionalization for the formation of C-C and C-heteroatom bond under transition-metal-catalysed and metal-free conditions.


Keywords


Metal-free; C-H bond activation; C-C bond formation; Transition-metal-catalyzed; C-heteroatom bond formation; Csp3-H bond functionalization

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DOI: 10.5155/eurjchem.7.2.248-270.1412

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Funding information


The National Natural Science Foundation of China (21562016), the Natural Science Foundation of the Guizhou Science and Technology Depart-ment (JZ [2014]2010) and the Science and Technology Planing Project of Guiyang city [(2012204)23], China.

Citations

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[1]. Zhengwei Yu, Saisai Zhang, Zengming Shen
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[2]. Alexander Breder, Christian Depken
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[3]. Catherine A. Moulder, Thomas R. Cundari
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[4]. Carly C. Carter, Thomas R. Cundari
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[5]. Alexander Breder, Christian Depken
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How to cite


Cai, X.; Jin, J.; Xie, B. Eur. J. Chem. 2016, 7(2), 248-270. doi:10.5155/eurjchem.7.2.248-270.1412
Cai, X.; Jin, J.; Xie, B. Recent advance in direct sp3 carbon-hydrogen bond functionalizations. Eur. J. Chem. 2016, 7(2), 248-270. doi:10.5155/eurjchem.7.2.248-270.1412
Cai, X., Jin, J., & Xie, B. (2016). Recent advance in direct sp3 carbon-hydrogen bond functionalizations. European Journal of Chemistry, 7(2), 248-270. doi:10.5155/eurjchem.7.2.248-270.1412
Cai, Xiao-Hua, Jun Jin, & Bing Xie. "Recent advance in direct sp3 carbon-hydrogen bond functionalizations." European Journal of Chemistry [Online], 7.2 (2016): 248-270. Web. 30 Oct. 2020
Cai, Xiao-Hua, Jin, Jun, AND Xie, Bing. "Recent advance in direct sp3 carbon-hydrogen bond functionalizations" European Journal of Chemistry [Online], Volume 7 Number 2 (30 June 2016)

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