European Journal of Chemistry 2016, 7(3), 309-314 | doi: https://doi.org/10.5155/eurjchem.7.3.309-314.1450 | Get rights and content






  OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Novel approach for UPLC-ESI-Tandem mass spectrometric method for simultaneous determination of olmesartan medoxomil and hydrochlorothiazide in their pharmaceutical combination with kinetic studies of forced degradation


Ahmed Abdalazim Mostafa (1,*) , Maha Mahmoud Abou-El Alamin (2)

(1) Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(2) Analytical Chemistry Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt
(*) Corresponding Author

Received: 11 May 2016 | Revised: 21 Jun 2016 | Accepted: 02 Jul 2016 | Published: 30 Sep 2016 | Issue Date: September 2016

Abstract


A simple, robust ultra-performance liquid chromatography coupled to ESI-Tandem mass spectrometric (UPLC-MS/MS) technique was developed for the simultaneous quantitation of olmesartan medoxomil (OLM) and hydrochlorothiazide (HCT) in bulk and their combined pharmaceutical formulation. Chromatographic separation was done on a Hypersil gold 50×2.1 mm (1.9 μm) column, with gradient elution of mobile phase consisted of acetonitrile and 0.1% formic acid aqueous solution. Detection of analytes was carried out using selective reaction monitoring (SRM) mode on a triple quadrupole mass spectrometer coupled with electrospray ionization (ESI). Linearity was achieved over concentration ranges of 2.0-200.0 and 3.0-50.0 ng/mL for OLM and HCT, respectively. Intra and inter day reproducibility were acceptable. The lower limits of detection were found to be 0.627 and 0.583 ng/mL and lower limits of quantitation were 1.900 and 1.767 ng/mL for OLM and HCT, respectively. The method was successfully applied for determination the cited drugs in their combined pharmaceutical dosage form. The method was applied to study the kinetic of forced degradation of both drugs under different conditions. The method was validated according to ICH guidelines and there is no significance difference between the proposed method and the reported method. The simplicity and sensitivity of this method allows the utilization of method in quality control of the cited drugs.


Keywords


UPLC; Olmesartan; Hydrochlorothiazide; Kinetic degradation; Pharmaceutical dosage form; Tandem mass spectrometric technique

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.7.3.309-314.1450

Links for Article


| | | | | | |

| | | | | | |

Related Articles




Article Metrics

This Abstract was viewed 706 times | PDF Article downloaded 228 times

Funding information


The Pharmaceutical Services Centre and LC-MS Unit, Faculty of Pharmacy, Helwan University, Cairo, Egypt

Citations

/


[1]. Selvia Maged Adly, Maha Mohamed Abdelrahman, Nada Sayed Abdelwahab, Nourudin Wageh Ali
Different spectrophotometric and TLC-densitometric methods for determination of olmesartan medoxomil and hydrochlorothiazide and their degradation products
European Journal of Chemistry  9(4), 400, 2018
DOI: 10.5155/eurjchem.9.4.400-407.1784
/


References

[1]. Bramlage, P.; Zemmrich, C.; Ketelhut, R.; Wolf, W. P.; Fronk, E. M.; Schmieder, R. E. Vasc. Health Risk Manag. 2013, 9, 475-483.
http://dx.doi.org/10.2147/VHRM.S49118

[2]. Mohan, J. C.; Jain, R.; Chamle, V.; Bhargava, A. J. Clin. Diagn. Res. 2015, 9(8), OC10-3.

[3]. Chrysant, S. G.; Weber, M. A.; Wang, A. C.; Hinman, D. J. Am. Soc. Hypertens 2004, 17, 252-259.
http://dx.doi.org/10.1016/j.amjhyper.2003.11.003

[4]. Sellin, L.; Stegbauer, J.; Laeis, P.; Rump, L. C. J. Hyperten. 2005, 23, 2083-2092.
http://dx.doi.org/10.1097/01.hjh.0000186022.74245.01

[5]. Laeis, P.; Püchler, K.; Kirch, W. J. Hypertens Suppl. 2001, 19(1), S21-32.
http://dx.doi.org/10.1097/00004872-200106001-00004

[6]. Rote, A. R.; Bari, P. D. Indian J. Pharm. Sci. 2010, 72, 111-113.
http://dx.doi.org/10.4103/0250-474X.62245

[7]. Merey, H. A.; Ramadan, N. K.; Diab, S. S.; Moustafa, A. A. Spectrochim. Acta A 2014, 125, 138-146.
http://dx.doi.org/10.1016/j.saa.2014.01.095

[8]. Darwish, H. W. Chem. Cent. J. 2013, 7, 22-22.
http://dx.doi.org/10.1186/1752-153X-7-22

[9]. Solanki, T. B.; Shah, P. A.; Patel, K. G. Indian J. Pharm. Sci. 2014, 76, 179-187.

[10]. Verma, P. K.; Kamboj, V. K. Pak. J. Pharm. Sci. 2013, 26(1), 209-215.

[11]. Vidyadhara, S.; Reddyvalam, L. C. S.; Rao, B. V.; Tejaswi, K.; Reshma, M. Oriental J. Chem. 2014, 30(1), 195-201.

[12]. Yunoos, M.; Sankar, D. G. Int. J. Pharm. Sci. Drug. Res. 2015, 7(3), 290-297.

[13]. Srikanth, R. R.; Murali, K. R.; Vekaria, N. A.; Rao, S. V.; Mantena, B. P. V. J. Chromatogr. B. 2015, 38, 1343-1354.

[14]. Gorain, B.; Choudhury, H.; Biswas, E.; Barik, A.; Jaisankar, P.; Pal, T. K. RSC Advances 2013, 3, 10887-10893.
http://dx.doi.org/10.1039/c3ra41452c

[15]. Kumar, A.; Verma, P. R. P.; Monif, T.; Khuroo, A. H.; Iyer, S. S.; Singh, A. K. J. Chromatogr. B. 2012, 35, 59-78.

[16]. Chae, J. W.; Baek, I. H.; Seo, J. W.; Jung, S. H.; Back, H. M.; Song, B. J.; Lee, B. Y.; Yun, H. Y.; Kang, W.; Kwon, K. I. Int. J. Clin. Pharmacol. Ther. 2014, 52(8), 676-683.
http://dx.doi.org/10.5414/CP202046

[17]. Ebeid, W. M.; Elkady, E. F.; El-Zaher, A. A.; El-Bagary, R. I.; Patonay, G. Anal. Bioanal. Chem. 2014, 406, 6701-6712.
http://dx.doi.org/10.1007/s00216-014-8085-0

[18]. Kumar, K. K.; Rao, C. K.; Madhusudan, G.; Mukkanti, K. Am. J. Analyt. Chem. 2012, 3, 50-58.
http://dx.doi.org/10.4236/ajac.2012.31008

[19]. Jain, P. S.; Patel, M. K.; Gorle, A. P.; Chaudhari, A. J.; Surana, S. J. J. Chromatogr. Sci. 2012, 50, 680-687.
http://dx.doi.org/10.1093/chromsci/bms067

[20]. Mowaka, S.; Mohamed, D. RSC Advances 2015, 5, 60467-60481.
http://dx.doi.org/10.1039/C5RA11448A

[21]. Mohamed, D; Mowaka, S.; Mostafa, A. Eur. J. Chem. 2014, 5, 181-85.
http://dx.doi.org/10.5155/eurjchem.5.1.181-185.942

[22]. ICH Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology, Q2(R1), Current Step 4 Version, Parent Guidelines on Methodology, 2005.

[23]. Shrivastava, A.; Gupta, V. Methods for the determination of limit of detection and limit of quantitation of the analytical methods, 2011; Vol. 2.

[24]. El-Gizawy, S. M.; Abdelmageed, O. H.; Omar, M. A.; Deryea, S. M.; Abdel-Megied, A. M. Am. J. Analyt. Chem. 2012, 3, 422-430.
http://dx.doi.org/10.4236/ajac.2012.36055

[25]. Adamovics, J. A. Chromatographic analysis of pharmaceuticals; Marcel Dekker Inc., New York, 1997.

[26]. ICH Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology, Q2 (R1), Current Step 4 Version, Parent Guidelines on Methodology Dated November 6; 1996, incorporated in November 2005.

[27]. Murakami, T.; Konno, H.; Fukutsu, N.; Onodera, M.; Kawasaki, T.; Kusu, F. J. Pharm. Biomed. Anal. 2008, 47, 553-559.
http://dx.doi.org/10.1016/j.jpba.2008.02.021

[28]. Mahajan, A. A.; Thaker, A. K.; Mohanraj, K. J. Brazilian Chem. Soc. 2012, 23, 445-452.

[29]. Gorog, S. J. Pharm. Biomed. Anal. 2008, 48, 247-253.
http://dx.doi.org/10.1016/j.jpba.2007.10.038

[30]. Florence, D. A. A. T. Physicochemical Principles of Pharmacy, Macmillan Press, London 1998.
http://dx.doi.org/10.1007/978-1-349-14416-7

How to cite


Mostafa, A.; Abou-El Alamin, M. Eur. J. Chem. 2016, 7(3), 309-314. doi:10.5155/eurjchem.7.3.309-314.1450
Mostafa, A.; Abou-El Alamin, M. Novel approach for UPLC-ESI-Tandem mass spectrometric method for simultaneous determination of olmesartan medoxomil and hydrochlorothiazide in their pharmaceutical combination with kinetic studies of forced degradation. Eur. J. Chem. 2016, 7(3), 309-314. doi:10.5155/eurjchem.7.3.309-314.1450
Mostafa, A., & Abou-El Alamin, M. (2016). Novel approach for UPLC-ESI-Tandem mass spectrometric method for simultaneous determination of olmesartan medoxomil and hydrochlorothiazide in their pharmaceutical combination with kinetic studies of forced degradation. European Journal of Chemistry, 7(3), 309-314. doi:10.5155/eurjchem.7.3.309-314.1450
Mostafa, Ahmed, & Maha Mahmoud Abou-El Alamin. "Novel approach for UPLC-ESI-Tandem mass spectrometric method for simultaneous determination of olmesartan medoxomil and hydrochlorothiazide in their pharmaceutical combination with kinetic studies of forced degradation." European Journal of Chemistry [Online], 7.3 (2016): 309-314. Web. 3 Aug. 2020
Mostafa, Ahmed, AND Abou-El Alamin, Maha. "Novel approach for UPLC-ESI-Tandem mass spectrometric method for simultaneous determination of olmesartan medoxomil and hydrochlorothiazide in their pharmaceutical combination with kinetic studies of forced degradation" European Journal of Chemistry [Online], Volume 7 Number 3 (30 September 2016)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item


DOI Link: https://doi.org/10.5155/eurjchem.7.3.309-314.1450

| | | | | | |

| | | | | |

Save to Zotero Save to Mendeley



European Journal of Chemistry 2016, 7(3), 309-314 | doi: https://doi.org/10.5155/eurjchem.7.3.309-314.1450 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)




© Copyright 2010 - 2020  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2020 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.

hatay escort hatay escort corlu escort corum escort burgaz escort giresun escort aydin escort ordu escort erzincan escort hatay escort sivas escort rize escort edirne escort aksaray escort kibris escort isparta escort erzurum escort tekirdag escort usak escort urfa escort kastamonu escort kibris escort manisa escort giresun escort urfa escort nevsehir escort sivas escort yalova escort ordu escort hatay escort yalova escort amasya escort kayseri escort ordu escort maras escort canakkale escort yalova escort balikesir escort manisa escort urfa escort mugla escort trabzon escort bolu escort corlu escort diyarbakir escort isparta escort kutahya escort elazig escort erzurum escort sakarya escort afyon escort kutahya escort konya escort agri escort cesme escort sinop escort sivas escort konya escort kibris escort adapazari escort luleburgaz escort adana escort kibris escort rize escort sakarya escort alanya escort isparta escort burdur escort konya escort bitlis escort canakkale escort sivas escort amasya escort mus escort aydin escort van escort yalova escort kastamonu escort mardin escort bolu escort afyon escort sakarya escort isparta escort tokat escort trakya escort bayburt escort urfa escort mardin escort