European Journal of Chemistry 2017, 8(4), 339-343 | doi: https://doi.org/10.5155/eurjchem.8.4.339-343.1614 | Get rights and content






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Conductometric determination of naproxen in bulk and pharmaceutical dosage form


Hassan Ahmad Alhazmi (1,*) , Mohammed Al Bratty (2)

(1) Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Jazan University, 45142, Jazan, Kingdom of Saudi Arabia
(2) Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Jazan University, 45142, Jazan, Kingdom of Saudi Arabia
(*) Corresponding Author

Received: 26 Jul 2017 | Revised: 15 Sep 2017 | Accepted: 20 Sep 2017 | Published: 31 Dec 2017 | Issue Date: December 2017

Abstract


This study aimed at the development of simple and cheap conductometric method that can be used for the determination of naproxen in bulk and dosage forms. During the study, naproxen was titrated with sodium hydroxide (Method A) and potassium hydroxide (Method B) and the end points were determined with conductivity cell. Variables affecting the end point determination were also studied in the range of 1-10 mg/mL of naproxen. The proposed methods were validated by precision and recovery studies. The percentage recoveries ranged from 99.15±0.659 and 101.13±0.543 with % RSD of 0.897 and 0.749 with sodium hydroxide and potassium hydroxide, respectively. The methods were effectively applied for the determination of naproxen in tablet dosage form. The methods proposed in this study can be used as substitute for more composite and classy methods used for the determination of naproxen and are highly reproducible as compared to other reported methods.


Keywords


Naproxen; Conductivity; Inflammation; Sodium hydroxide; Analytical methods; Pharmaceutical dosage form

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DOI: 10.5155/eurjchem.8.4.339-343.1614

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Funding information


Jazan University, 45142, Jazan, Kingdom of Saudi Arabia and Exela Pharmsci. Pvt. Ltd., Kingdom of Saudi Arabia

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How to cite


Alhazmi, H.; Al Bratty, M. Eur. J. Chem. 2017, 8(4), 339-343. doi:10.5155/eurjchem.8.4.339-343.1614
Alhazmi, H.; Al Bratty, M. Conductometric determination of naproxen in bulk and pharmaceutical dosage form. Eur. J. Chem. 2017, 8(4), 339-343. doi:10.5155/eurjchem.8.4.339-343.1614
Alhazmi, H., & Al Bratty, M. (2017). Conductometric determination of naproxen in bulk and pharmaceutical dosage form. European Journal of Chemistry, 8(4), 339-343. doi:10.5155/eurjchem.8.4.339-343.1614
Alhazmi, Hassan, & Mohammed Al Bratty. "Conductometric determination of naproxen in bulk and pharmaceutical dosage form." European Journal of Chemistry [Online], 8.4 (2017): 339-343. Web. 5 Jun. 2020
Alhazmi, Hassan, AND Al Bratty, Mohammed. "Conductometric determination of naproxen in bulk and pharmaceutical dosage form" European Journal of Chemistry [Online], Volume 8 Number 4 (31 December 2017)

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DOI Link: https://doi.org/10.5155/eurjchem.8.4.339-343.1614

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