European Journal of Chemistry 2019, 10(1), 30-36. doi:10.5155/eurjchem.10.1.30-36.1791

Synthesis and antimicrobial activity of some new pyrazoline derivatives bearing sulfanilamido moiety


Maysoon Mohammed Almahdi (1,*) orcid , Ahmed Elsadig Mohammed Saeed (2) orcid , Nadia Hanafy Metwally (3) orcid

(1) Department of Chemistry, College of Education, Alzaiem Alazhari University, 1432, Khartoum, Sudan
(2) Department of Chemistry, College of Science, Sudan University of Science and Technology, 407, Khartoum, Sudan
(3) Department of Chemistry, Faculty of Science, Cairo University, 12613, Giza, Egypt
(*) Corresponding Author

Received: 27 Sep 2018, Accepted: 08 Nov 2018, Published: 31 Mar 2019

Abstract


In the present study, a series of new pyrazoline derivatives bearing sulfanilamido moiety were synthesized and obtained in good yields. The chemical structures of the compounds were elucidated by spectral data (FT-IR, MS, UV-VIS and NMR). The synthesized compounds 41-70 were screened for their antimicrobial activity and compared with controls. The in vitro antibacterial activity of compounds 41-45 and 48-57 was checked against two Gram positive microorganisms (S. aureus and S. mutans) and three Gram negative microorganisms (E. coli, K. pneumonia and P. aureginosa), their antifungal activity was checked against C. albicans. The preliminary results showed that these compounds had moderate activity against the tested organisms. Compounds 41, 48, 51 and 56 exhibited promising antimicrobial activity against S. aureus compared to standard drug Ampicilin. Final synthesized compounds 58-70 were tested against two Gram positive (S. aureus and B. subtilis) and two Gram negative (E. coli and P. aureginosa) microorganisms, their activity against C. albicans was also checked and they did not exhibit any antimicrobial activity.


Keywords


Synthesis; Cyclization; Sulfadoxine; 2-Pyrazoline; Sulfanilamide; Antimicrobial activity

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DOI: 10.5155/eurjchem.10.1.30-36.1791

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[1]. Mohammad Asad, Muhammad Nadeem Arshad, Salman A. Khan, Mohammad Oves, Muhammad Khalid, Abdullah M. Asiri, Ataualpa A.C. Braga
Cyclization of chalcones into N-propionyl pyrazolines for their single crystal X-ray, computational and antibacterial studies
Journal of Molecular Structure  1201, 127186, 2020
DOI: 10.1016/j.molstruc.2019.127186
/


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How to cite


Almahdi, M.; Saeed, A.; Metwally, N. Eur. J. Chem. 2019, 10(1), 30-36. doi:10.5155/eurjchem.10.1.30-36.1791
Almahdi, M.; Saeed, A.; Metwally, N. Synthesis and antimicrobial activity of some new pyrazoline derivatives bearing sulfanilamido moiety. Eur. J. Chem. 2019, 10(1), 30-36. doi:10.5155/eurjchem.10.1.30-36.1791
Almahdi, M., Saeed, A., & Metwally, N. (2019). Synthesis and antimicrobial activity of some new pyrazoline derivatives bearing sulfanilamido moiety. European Journal of Chemistry, 10(1), 30-36. doi:10.5155/eurjchem.10.1.30-36.1791
Almahdi, Maysoon, Ahmed Elsadig Mohammed Saeed, & Nadia Hanafy Metwally. "Synthesis and antimicrobial activity of some new pyrazoline derivatives bearing sulfanilamido moiety." European Journal of Chemistry [Online], 10.1 (2019): 30-36. Web. 18 Nov. 2019
Almahdi, Maysoon, Saeed, Ahmed, AND Metwally, Nadia. "Synthesis and antimicrobial activity of some new pyrazoline derivatives bearing sulfanilamido moiety" European Journal of Chemistry [Online], Volume 10 Number 1 (31 March 2019)

DOI Link: https://doi.org/10.5155/eurjchem.10.1.30-36.1791

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