European Journal of Chemistry 2012, 3(1), 65-70 | doi: https://doi.org/10.5155/eurjchem.3.1.65-70.518 | Get rights and content






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Synthesis of novel 2-propenoyl amides, esters, heterocyclic compounds and their screening as antifungal and antibacterial agents


Ahmed El-Ziaty (1,*) , Abdelaal Abdalh (2) , Ashraf Hamed (3) , Sayed Shiba (4) , Abdelhafed Abdullha (5)

(1) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(2) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(3) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(4) Chemistry Department, Faculty of Science and Hummanities, Shaqra University, 11962, Harmala, Saudia Arabia
(5) Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
(*) Corresponding Author

Received: 03 Sep 2011 | Revised: 10 Nov 2011 | Accepted: 26 Sep 2011 | Published: 31 Mar 2012 | Issue Date: March 2012

Abstract


Compound, 2-cyano-3-(2ˊ,4ˊ-dichlorophenyl)-2-prpoenoyl chloride, 3, was reacted with nitrogen, sulfur, and oxygen nucleophilic reagents to give new 2-propenoyl amide and ester derivatives. Some of these derivatives were cyclized under the reaction conditions and/or with POCl3 or Ac2O to give new derivatives of heterocyclic systems. Some of these compounds were tested as antibacterial and antifungal agents.

3_1_65_70_800


Keywords


Oxadiazole; Benzoxazinone; Pyridopyrimidine; 2-Propenoyl amide; 2-Propenoyl chloride; Antibacterial activities

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DOI: 10.5155/eurjchem.3.1.65-70.518

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Funding information


Micro Analytical Center, Cairo University, Egypt

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How to cite


El-Ziaty, A.; Abdalh, A.; Hamed, A.; Shiba, S.; Abdullha, A. Eur. J. Chem. 2012, 3(1), 65-70. doi:10.5155/eurjchem.3.1.65-70.518
El-Ziaty, A.; Abdalh, A.; Hamed, A.; Shiba, S.; Abdullha, A. Synthesis of novel 2-propenoyl amides, esters, heterocyclic compounds and their screening as antifungal and antibacterial agents. Eur. J. Chem. 2012, 3(1), 65-70. doi:10.5155/eurjchem.3.1.65-70.518
El-Ziaty, A., Abdalh, A., Hamed, A., Shiba, S., & Abdullha, A. (2012). Synthesis of novel 2-propenoyl amides, esters, heterocyclic compounds and their screening as antifungal and antibacterial agents. European Journal of Chemistry, 3(1), 65-70. doi:10.5155/eurjchem.3.1.65-70.518
El-Ziaty, Ahmed, Abdelaal Abdalh, Ashraf Hamed, Sayed Shiba, & Abdelhafed Abdullha. "Synthesis of novel 2-propenoyl amides, esters, heterocyclic compounds and their screening as antifungal and antibacterial agents." European Journal of Chemistry [Online], 3.1 (2012): 65-70. Web. 3 Aug. 2020
El-Ziaty, Ahmed, Abdalh, Abdelaal, Hamed, Ashraf, Shiba, Sayed, AND Abdullha, Abdelhafed. "Synthesis of novel 2-propenoyl amides, esters, heterocyclic compounds and their screening as antifungal and antibacterial agents" European Journal of Chemistry [Online], Volume 3 Number 1 (31 March 2012)

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DOI Link: https://doi.org/10.5155/eurjchem.3.1.65-70.518

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