European Journal of Chemistry

Synthesis of novel 2-propenoyl amides, esters, heterocyclic compounds and their screening as antifungal and antibacterial agents

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Published: Mar 31, 2012
DOI: https://doi.org/10.5155/eurjchem.3.1.65-70.518
Keywords:
Oxadiazole, Benzoxazinone, Pyridopyrimidine, 2-Propenoyl amide, 2-Propenoyl chloride, Antibacterial activities
Section
Research Article
Issue
Vol. 3 No. 1 (2012): March 2012
Dates
Received 2011-09-03
Accepted 2011-09-26
Published 2012-03-31


Main Article Content

Ahmed El-Ziaty
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
Abdelaal Abdalh
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
Ashraf Hamed
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt
Sayed Shiba
Chemistry Department, Faculty of Science and Hummanities, Shaqra University, 11962, Harmala, Saudia Arabia
Abdelhafed Abdullha
Chemistry Department, Faculty of Science, Ain Shams University, Abbassia 11566, Cairo, Egypt

Abstract

Compound, 2-cyano-3-(2ˊ,4ˊ-dichlorophenyl)-2-prpoenoyl chloride, 3, was reacted with nitrogen, sulfur, and oxygen nucleophilic reagents to give new 2-propenoyl amide and ester derivatives. Some of these derivatives were cyclized under the reaction conditions and/or with POCl3 or Ac2O to give new derivatives of heterocyclic systems. Some of these compounds were tested as antibacterial and antifungal agents.

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El-Ziaty, A.; Abdalh, A.; Hamed, A.; Shiba, S.; Abdullha, A. Synthesis of Novel 2-Propenoyl Amides, Esters, Heterocyclic Compounds and Their Screening As Antifungal and Antibacterial Agents. Eur. J. Chem. 2012, 3, 65-70.

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Micro Analytical Center, Cairo University, Egypt
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