European Journal of Chemistry 2011, 2(4), 539-543. doi:10.5155/eurjchem.2.4.539-543.55

Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines


Emtithal Ahmed El-Sawi (1,*) , Tahia Bayoumy Mostafa (2) , Hyam Ali Radwan (3)

(1) Chemistry Department, Faculty of Girls for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, 11757, Egypt
(2) Chemistry Department, Faculty of Girls for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, 11757, Egypt
(3) Chemistry Department, Faculty of Girls for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo, 11757, Egypt
(*) Corresponding Author

Received: 11 Apr 2010, Accepted: 05 Jun 2010, Published: 31 Dec 2011

Abstract


Isatin-3-imine derivatives (1a-d) have been synthesized. These compounds were then converted into phosphorylated products 2a, 2c with triethylphosphite and 3a-d with triphenylphosphine. The structures of the new compounds were confirmed by elemental analyses, IR, UV/VIS, 1H NMR, 13C NMR and MS studies. The structure of compound 1a was also confirmed by single crystal X-ray diffraction studies. Compounds 1b-d and 3c-d exhibited potent antibacterial activity against Bacillus subtilis and Escherichia Coli. Compound 3a was found to exhibit antifungal activity against the tested organisms.

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Keywords


Mass spectroscopy; Phosphorylation; Triphenylphosphine; Schiff bases; X-ray crystallography; Antimicrobial activity

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DOI: 10.5155/eurjchem.2.4.539-543.55

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Citations

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[1]. V. U. Bhaskara Rao, Amol P. Jadhav, Dnyaneshwar Garad, Ravi P. Singh
Asymmetric Vinylogous Mannich Reaction of Silyloxy Furans with N-tert-Butanesulfinyl Ketimines
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[2]. Mona Hizkial Nasr Arsanious, Soher Said Maigali
Isatin Imines in the Reaction with Iminophosphine: X-Ray Structure of Phospholane Derivatives
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DOI: 10.1080/00397911.2013.800210
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[3]. Ivan Hameed Rouil Tomi, Amer Hasan Abdullah, Ali Hussein Raheemah Al-Daraji, Selma Abdul Rudha Abbass
Synthesis, characterization and comparative study the antibacterial activities of some imine-amoxicillin derivatives
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How to cite


El-Sawi, E.; Mostafa, T.; Radwan, H. Eur. J. Chem. 2011, 2(4), 539-543. doi:10.5155/eurjchem.2.4.539-543.55
El-Sawi, E.; Mostafa, T.; Radwan, H. Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines. Eur. J. Chem. 2011, 2(4), 539-543. doi:10.5155/eurjchem.2.4.539-543.55
El-Sawi, E., Mostafa, T., & Radwan, H. (2011). Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines. European Journal of Chemistry, 2(4), 539-543. doi:10.5155/eurjchem.2.4.539-543.55
El-Sawi, Emtithal, Tahia Bayoumy Mostafa, & Hyam Ali Radwan. "Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines." European Journal of Chemistry [Online], 2.4 (2011): 539-543. Web. 13 Nov. 2019
El-Sawi, Emtithal, Mostafa, Tahia, AND Radwan, Hyam. "Synthesis and biological activity of functionalized phosphorus derivatives of isatin imines" European Journal of Chemistry [Online], Volume 2 Number 4 (31 December 2011)

DOI Link: https://doi.org/10.5155/eurjchem.2.4.539-543.55

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