European Journal of Chemistry

Synthesis of some novel 1,2,4-triazole derivatives as potential antimicrobial agents

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Published: Jun 30, 2013
DOI: https://doi.org/10.5155/eurjchem.4.2.92-97.615
Keywords:
Quinoline, 1, 2, 4-Triazole, Spectroscopy, Antifungal activities, Antibacterial activities, 4-Triazolo[3, 4-b]thiadiazole
Section
Research Article
Issue
Vol. 4 No. 2 (2013): June 2013
Dates
Received 2012-04-18
Accepted 2012-06-05
Published 2013-06-30


Main Article Content

Mohamed Sayed Behalo
Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
Aly Abdelmaboud Aly
Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
Ashraf Farouk Wasfy
Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt
Marwa Mohamed Rizk
Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt

Abstract

An efficient synthesis of 1,2,4-triazole derivatives, fused to five and six membered rings from 4-amino-5-[(quinolin-8-yloxy)methyl]-4H-1,2,4-triazole-3-thiole (2) was described. The structural formula of all derivatives was confirmed and characterized by elemental analysis and spectral studies. Some of the synthesized compounds were also investigated for their antibacterial and antifungal activities and compared with standard drugs. Most of the tested compounds demonstrated potent to weak antimicrobial activities.

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Behalo, M. S.; Aly, A. A.; Wasfy, A. F.; Rizk, M. M. Synthesis of Some Novel 1,2,4-Triazole Derivatives As Potential Antimicrobial Agents. Eur. J. Chem. 2013, 4, 92-97.

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Chemistry Department, Faculty of Science, Benha University, Egypt
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