European Journal of Chemistry

Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones



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Shadia Ahmed Galal
Ahmed S. Abdelsamie
Mireya L. Rodriguez
Sean M. Kerwin
Hoda I. El Diwani

Abstract

The influence of the incorporation of 1,3,4-oxadiazole ring into 2-methyl-1H-benzimidazole derivatives producing a series of substituted 5(6)-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazoles on the antitumor activity was studied in this study. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7 and lung cancer cell line A549. S-5-(2-methyl-1H-benzo[d]imidazol-5-yl)-1,3,4-oxadiazol-2-yl 2-nitrobenzenesulfonothioate (9) showed potent activity against both MCF-7 and A549 cell lines. Whereas, compounds 7, 11-13 and 15-17 have moderate growth inhibitory activity on the two cell lines.

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Galal, S. A.; Abdelsamie, A. S.; Rodriguez, M. L.; Kerwin, S. M.; El Diwani, H. I. Synthesis and Studying the Antitumor Activity of Novel 5-(2-Methylbenzimidazol-5-Yl)-1,3,4-Oxadiazole-2(3H)-Thiones. Eur. J. Chem. 2010, 1, 67-72.

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US-Egypt Joint Science and Technology Board Fund, Administered through the USDA (BIO9-002-015)
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