European Journal of Chemistry

Synthesis and studying the antitumor activity of novel 5-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazole-2(3H)-thiones

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Published: Jun 15, 2010
DOI: https://doi.org/10.5155/eurjchem.1.2.67-72.1
Keywords:
Salicylate, Hydrogen bonding, DFT-Molecular dynamics, Vibrational spectroscopy, Relaxation spectroscopy
Section
Research Article
Issue
Vol. 1 No. 2 (2010): June 2010
Dates
Received 2010-03-23
Accepted 2010-04-30
Published 2010-06-15


Main Article Content

Shadia Ahmed Galal
Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Dokki, 12622, Cairo, Egypt
Ahmed S. Abdelsamie
Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Dokki, 12622, Cairo, Egypt
Mireya L. Rodriguez
Department of Chemistry and Biochemistry, Division of Medicinal Chemistry and Institute for Cellular and Molecular Biology, The University of Texas, Austin, TX 78712 USA
Sean M. Kerwin
Department of Chemistry and Biochemistry, Division of Medicinal Chemistry and Institute for Cellular and Molecular Biology, The University of Texas, Austin, TX 78712 USA
Hoda I. El Diwani
Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Dokki, 12622, Cairo, Egypt

Abstract

The influence of the incorporation of 1,3,4-oxadiazole ring into 2-methyl-1H-benzimidazole derivatives producing a series of substituted 5(6)-(2-methylbenzimidazol-5-yl)-1,3,4-oxadiazoles on the antitumor activity was studied in this study. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7 and lung cancer cell line A549. S-5-(2-methyl-1H-benzo[d]imidazol-5-yl)-1,3,4-oxadiazol-2-yl 2-nitrobenzenesulfonothioate (9) showed potent activity against both MCF-7 and A549 cell lines. Whereas, compounds 7, 11-13 and 15-17 have moderate growth inhibitory activity on the two cell lines.

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Galal, S. A.; Abdelsamie, A. S.; Rodriguez, M. L.; Kerwin, S. M.; El Diwani, H. I. Synthesis and Studying the Antitumor Activity of Novel 5-(2-Methylbenzimidazol-5-Yl)-1,3,4-Oxadiazole-2(3H)-Thiones. Eur. J. Chem. 2010, 1, 67-72.

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US-Egypt Joint Science and Technology Board Fund, Administered through the USDA (BIO9-002-015)
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