European Journal of Chemistry

Synthesis, characterization and in vitro biological evaluation of some new 1,3,5-triazine-bis-azomethine hybrid molecules as potential antitubercular agents



Main Article Content

Madhusudana Rao Gajula
Yellala Venkata Rami Reddy

Abstract

A series of 1,3,5-triazine-bis-azomethinehybrid molecules (4a-p and 5a-p) were synthesized and tested against Mycobacterium tuberculosis H37Rv strain. Preparation of the titled compounds was achieved by reaction of N-(4-aminobenzylidene)-4-methoxy-6-methyl-1,3,5-triazin-2-amine (3) with aromatic/heteroaromatic aldehydes (4a-p)and ketones (5a-p). Among the compounds tested, (4d) was identified as the most active in vitro with MIC value 3.125 µg/mL against Mycobacterium tuberculosis H37Rv.


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Gajula, M. R.; Reddy, Y. V. R. Synthesis, Characterization and in Vitro Biological Evaluation of Some New 1,3,5-Triazine-Bis-Azomethine Hybrid Molecules As Potential Antitubercular Agents. Eur. J. Chem. 2014, 5, 374-379.

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