European Journal of Chemistry

A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents

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Published: Sep 30, 2014
DOI: https://doi.org/10.5155/eurjchem.5.3.517-525.1072
Keywords:
Triazoles, Pyrazoles, Pyridazines, Oxadiazoles, One-pot reaction, Antimicrobial activity
Section
Research Article
Issue
Vol. 5 No. 3 (2014): September 2014
Dates
Received 2014-04-10
Accepted 2014-06-06
Published 2014-09-30


Main Article Content

Shawkat Ahmed Abdelmohsen
Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt

Abstract

Synthesis of ethyl 6-(8-hydroxyquinolin-5-yl)-3-methylpyridazin-4-carboxylate (4) via one-pot three component reaction of ethyl acetoacetate with (8-hydroxyquinolin-5-yl)(oxo) acetaldehyde (2) in the presence of hydrazine hydrate at room temperature in water was described. A new series of heterocyclic moieties such as oxadiazoles, triazoles, pyrazoles and Schiff bases were prepared and characterized. The structures of the newly synthesized compounds were established by elemental and spectral data. The antimicrobial activity of some of the synthesized compounds was examined against two Gram‐positive bacteria, two Gram‐negative bacteria and four fungi. The results showed that the tested compounds exhibited significant to moderate antimicrobial.


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Abdelmohsen, S. A. A Convenient Synthesis and Preparation of the Derivatives of Ethyl-6-(8-Hydroxyquinolin-5-Yl)-3-Methylpyridazine-4-Carboxylate As Antimicrobial Agents. Eur. J. Chem. 2014, 5, 517-525.

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